5288-67-5

Basic information

• Product Name: 7-(2-oxocyclopentyl)heptanoic acid
• CAS NO: 5288-67-5
• Molecular Formula: C₁₂H₂₀O₃
• Molecular Weight: 212.2854
• Mol File: 5288-67-5.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 369.8°C at 760 mmHg
• Flash Point: 191.6°C
• Density: 1.061g/cm³
• Vapor Pressure: 1.76E-06mmHg at 25°C
• Refractive Index: 1.484
• CAS DataBase Reference: 7-(2-oxocyclopentyl)heptanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(2-oxocyclopentyl)heptanoic acid(5288-67-5)
• EPA Substance Registry System: 7-(2-oxocyclopentyl)heptanoic acid(5288-67-5)

Safety Data

• Hazardous Substances Data: 5288-67-5(Hazardous Substances Data)

Usage

General Description

7-(2-oxocyclopentyl)heptanoic acid is a chemical compound with the molecular formula C11H18O3. It is a derivative of heptanoic acid, containing a cyclopentyl group and a ketone group. 7-(2-oxocyclopentyl)heptanoic acid is used in the synthesis of other organic compounds and may also have potential industrial or pharmaceutical applications. Its properties and uses make it an important chemical in various fields such as organic chemistry, pharmaceuticals, and materials science.

Upstream product

• 29823-18-5 ethyl 7-bromoheptanoate 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 54696-27-4 2-ethoxycarbonyl-2-<6',6'-bis(ethoxycarbonyl)hexyl>cyclopentanone 
• 58707-68-9 2-carboxyethoxy-2-(6'-methoxycarbonylhexyl)-cyclopentanone 
• 74845-09-3 5-(6-carbethoxyhexyl)-2-carbethoxycyclopentanone 
• 51876-14-3 7-(2-Hydroxy-cyclopentyl)-heptanoic acid 
• 1119-60-4 hept-6-enoic acid 
• 120-92-3 cyclopentanone 
• 5239-43-0 7-(5-oxo-1-cyclopenten-1-yl)heptanoic acid 
• 40491-73-4 Decahydro-cyclopentacyclononene-3a,4-diol 
• 111-24-0 1,5-dibromo-pentane 
• 1906-95-2 5-bromopentylmalonic acid diethyl ester 
• 54049-24-0 methyl 7-bromoheptanoate 
• 502-42-1 cycloheptanone 

Downstream Products

• 85421-76-7 2-(6-carboxyhexyl)cyclopentanone hexylhydrazone 
• 5239-43-0 7-(5-oxo-1-cyclopenten-1-yl)heptanoic acid 
• 85745-91-1 2-(6'-carboxy-1'E-hexylidene)cyclopentanone 
• 34546-57-1 2-(6-methoxycarbonylhexyl)cyclopent-2-en-1-one 
• 40098-24-6 2-(6-methoxycarbonylhexyl)-4-(tetrahydropyran-2-yloxy)cyclopent-2-enone 
• 40098-26-8 methyl 7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)heptanoate 

Relevant articles and documents

Synthesis of (±)-15-thia-15-deoxy-PGE1 methyl ester

The 15-thia-15-deoxy analogue of prostaglandin E1 methyl ester has been prepared by the zirconocene chloride mediated conjugate addition of an n-pentyl ethynyl sulfide derived anion to an appropriately substituted cyclopentenone. Similar methodology has also been used to prepare other 3-(3'-thia-1'-octenyl)-cyclopentanones.

SYNTHEISI OF 2-(ω'-CARBOXYALKYL)CYCLOALKANONES

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PRACTICAL SYNTHESIS OF 2-(6'-METHOXYCARBONYLHEXYL)CYCLOPENT-2-EN-1-ONE (PROSTAGLANDIN SYNTHON)

2-(6'-Methoxycarbonylhexyl)cyclopentanone was obtained by alkylation of the 2-(ethoxycarbonyl)cyclopentanone potassium salt with diethyl 5-bromopentylmalonate followed by acid cleavage of the obtained triester and esterification.Its bromination with copper bromide and dehydrobromination with collidine lead to 2-(6'-methoxycarbonylhexyl)cyclopent-2-en-1-one (a known prostaglandin synthon) with an overall yield of 28percent.The use of molecular bromine for bromination leads to the production of the 5-bromo analog of the synthon.