5308-12-3Relevant articles and documents
Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p- tolyl)] (R = Me, et and iPr)
Yeo, Chien Ing,Sim, Jiun-Horng,Khoo, Chai-Hoon,Goh, Zheng-Jie,Ang, Kok-Pian,Cheah, Yoke-Kqueen,Fairuz, Zainal Abidin,Halim, Siti Nadiah Binti Abdul,Ng, Seik Weng,Seng, Hoi-Ling,Tiekink, Edward R. T.
, p. 145 - 152 (2013/10/22)
The phosphanegold(I) thiocarbamides, Ph3PAu{SC(OR)=NC 6H4Me-4} for R = Me (1), Et (2) and iPr (3), have been shown to have essentially linear gold atom coordination geometries defined by phosphane-P and thiolate-S atoms, and exhibit minimum inhibitory concentration (MIC) values in the range of 1-37 μg/ml against four Gram-positive bacteria, namely Bacillus cereus, Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus; compounds 1-3 are less potent against a broad panel of 16 Gram-negative bacteria. As the minimum bactericidal concentration values were quite similar to the MIC values, compounds 1-3 are effective bactericidal agents. The specific action against the four Gram-positive bacteria suggests they function by inhibition of peptidoglycan synthesis.
3,4-diarylthiazolin-2-one or -2-thione derivatives, their methods of preparation and their uses in their methods of preparation and their uses in therapeutics
-
, (2008/06/13)
The present invention relates to derivatives of formula STR1 and to their use in therapeutics especially as drugs with anti-inflammatory and analgesic properties.
