5310-14-5

Basic information

• Product Name: N-methylthiobenzamide
• Synonyms: N-methylthiobenzamide;N-methylbenzenecarbothioamide
• CAS NO: 5310-14-5
• Molecular Formula: C₈H₉NS
• Molecular Weight: 151.23
• Mol File: 5310-14-5.mol
• Article Data: 38

Chemical Properties

• Melting Point: 81.5 °C(Solv: water (7732-18-5))
• Boiling Point: 225.1°C at 760 mmHg
• Flash Point: 90°C
• Appearance: /
• Density: 1.098g/cm³
• Vapor Pressure: 0.0879mmHg at 25°C
• Refractive Index: 1.6
• PKA: 12.45±0.70(Predicted)
• CAS DataBase Reference: N-methylthiobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methylthiobenzamide(5310-14-5)
• EPA Substance Registry System: N-methylthiobenzamide(5310-14-5)

Safety Data

• Hazardous Substances Data: 5310-14-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H9NS/c1-9-8(10)7-5-3-2-4-6-7/h2-6H,1H3,(H,9,10)

Upstream product

• 88070-48-8 N-methylbenzamide 
• 556-61-6 methyl thioisocyanate 
• 98-09-9 benzenesulfonyl chloride 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 74-89-5 methylamine 
• 942-91-6 Carboxymethyl dithiobenzoate 
• 622-29-7 N-Benzylidenemethylamine 
• 936-61-8 Thiobenzoic acid O-ethyl ester 
• 26668-52-0 C₁₃H₁₉N₃S₂ 
• 16430-05-0 Didehydro-4-methyl-5-phenyl-1,3,4-thiazolidin-2-on 
• 19703-86-7 Didehydro-4-methyl-5-phenyl-1,3,4-thiadiazolidin-2-thion 
• 1280-28-0 Anhydro-5-hydroxy-3-methyl-2-phenylthiazolium hydroxide 
• 3376-23-6 C-phenyl-N-methylnitrone 
• 6005-15-8 thiochromone 

Downstream Products

• 103-67-3 benzyl-methyl-amine 
• 58065-86-4 N-methyl-N-trimethylsilanyl-thiobenzamide 
• 31891-19-7 4-carboxy-3-methyl-2-phenyl-4,5-dihydro-thiazolium; bromide 
• 3472-76-2 (dichloro-phenyl-methyl)-carbonimidic acid dichloride 
• 91929-53-2 N-Methyl-thiobenzamid-S-oxyd (N-Methyl-thiobenzoyl-S-oxyd) 
• 26309-44-4 3-methyl-4-phenyl-[1,2,3]dithiazetium; chloride 
• 97213-13-3 N-Benzoyl-N-methyl-thiobenzoesaeureamid 
• 4115-21-3 N-methyl-N'-tosylbenzimidamide 
• 59073-57-3 N-Methylthiobenzimidsaeure-methylester-hydroiodid 
• 112423-02-6 3-Methyl-6-oxo-2,5-diphenyl-6H-1,3-thiazin-3-ium-4-olat 
• 121003-06-3 N-diphenylacetyl-N-methylthiobenzamide 
• 133399-27-6 N-Methyl-N-<(E)-2-methylbut-2-enoyl>thiobenzamide 
• 89861-53-0 C₁₂H₁₇NS₂ 
• 83241-86-5 N-Methyl-N-((E)-3-oxo-3-phenyl-propenyl)-thiobenzamide 

Relevant articles and documents

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Method for preparing aryl thioamide compound

The invention discloses a method for preparing an aryl thioamide compound. The method comprises the following steps: under the protection of inert gas, performing stirring to react for 6-12 hours at the reaction temperature of room temperature to 60 DEG C by taking aryl methanol as a substrate, sublimed sulfur as a sulfur source, an alkali metal complex formed by combining alkali metal salt and ligand as a catalyst, alkali as an accelerant, formamide as a solvent and an amine source; and carrying out post-treatment on the reaction product to obtain the aryl thioamide compound. According to theinvention, cheap and easily available aryl methanol is used as a substrate for three-component reaction to prepare the corresponding thioamide compound; the method for preparing the aryl thioamide compound has the technical advantages of simple technological process, high yield, less pollution, safety, environmental protection, greenness, mildness and the like.

Oxidative Coupling-Thionation of Amines Mediated by Iron-Based Imidazolium Salts for the Preparation of Thioamides

An efficient and selective multicomponent oxidative coupling, involving the use of two different amines, sodium phosphate, and elemental sulfur have been described for the preparation of thioamides, employing microwave irradiation. The use of an iron(III)-based imidazolium salt is essential as catalyst. Indeed, the iron-based catalyst is involved in the oxidative coupling of the two amines and in the subsequent C-S bond formation. The protocol is useful for a wide variety of primary benzylamines and alkylamines, as coupling partners. Thus, various electron-rich and electron-poor substituents in the aromatic rings and also fused piperidine derivatives, are suitable starting materials in this reaction. Some of the obtained products are important synthetic intermediates for natural products.