53101-04-5

Basic information

• Product Name: ETHYL 4-(4-NITROPHENYL)-1,3-THIAZOLE-2-CARBOXYLATE
• Synonyms: Ethyl 4-(4-nitrophenyl)-1,3-thiazole-2-carboxylate 95+%;4-(4-nitrophenyl)-2-Thiazolecarboxylic acid ethyl ester;ETHYL 4-(4-NITROPHENYL)-1,3-THIAZOLE-2-CARBOXYLATE;2-(Ethoxycarbonyl)-4-(4-nitrophenyl)-1,3-thiazole, 4-[2-(Ethoxycarbonyl)-1,3-thiazol-4-yl]nitrobenzene
• CAS NO: 53101-04-5
• Molecular Formula: C₁₂H₁₀N₂O₄S
• Molecular Weight: 278.2838
• Mol File: 53101-04-5.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 4-(4-NITROPHENYL)-1,3-THIAZOLE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(4-NITROPHENYL)-1,3-THIAZOLE-2-CARBOXYLATE(53101-04-5)
• EPA Substance Registry System: ETHYL 4-(4-NITROPHENYL)-1,3-THIAZOLE-2-CARBOXYLATE(53101-04-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 53101-04-5(Hazardous Substances Data)

Usage

Description

ETHYL 4-(4-NITROPHENYL)-1,3-THIAZOLE-2-CARBOXYLATE is a chemical compound that serves as a crucial reagent in the synthesis of various organic compounds, particularly 2-aminothiazoles and 2-thiazolecarboxamides. These synthesized compounds exhibit anti-anoxic activity, making them valuable in the development of pharmaceuticals and other applications.

Uses

Used in Pharmaceutical Industry:
ETHYL 4-(4-NITROPHENYL)-1,3-THIAZOLE-2-CARBOXYLATE is used as a reagent for the synthesis of 2-aminothiazoles and 2-thiazolecarboxamides, which possess anti-anoxic properties. These synthesized compounds are valuable in the development of pharmaceuticals targeting conditions that involve oxygen deprivation or ischemia.
Used in Chemical Research:
In the field of chemical research, ETHYL 4-(4-NITROPHENYL)-1,3-THIAZOLE-2-CARBOXYLATE is utilized as a key intermediate in the synthesis of complex organic molecules. Its role in creating 2-aminothiazoles and 2-thiazolecarboxamides contributes to the advancement of chemical knowledge and the discovery of new compounds with potential applications in various industries.

Upstream product

• 16982-21-1 ethyl 2-amino-2-thioxoacetate 
• 99-81-0 4-Nitrophenacyl bromide 
• 100-19-6 (4-nitrophenyl)ethanone 
• 617-36-7 Ethyl oxamate 
• 14527-42-5 thiazole-2-carboxylic acid ethyl ester 
• 928716-12-5 ethyl thiooxamate 

Downstream Products

• 491577-82-3 4-(4-amino-phenyl)-thiazole-2-carboxylic acid ethyl ester 
• 950603-75-5 C₃₄H₄₈ClN₃O₅SSi 
• 4415-05-8 4-(4-nitrophenyl)thiazole-2-carboxylic acid 
• 1314248-41-3 2-chloro-(4-methylsulfonyl)-N-(4-(thiazol-4-yl)phenyl)benzamide 
• 1314250-27-5 2-chloro-(4-methylsulfonyl)-N-(4-(2-ethoxycarbonylthiazol-4-yl)phenyl)benzamide 
• 60759-10-6 4-(4-aminophenyl)thiazole 
• 1314248-40-2 2-chloro-N-(4-(thiazol-4-yl)phenyl)benzamide 
• 1314248-42-4 2-chloro-N-(4-(2-(2-hydroxypropan-2-yl)thiazol-4-yl)phenyl)-4-(methylsulfonyl)benzamide 
• 1314248-43-5 2-chloro-N-(4-(2-(hydroxymethyl)thiazol-4-yl)phenyl)-4-(methylsulfonyl)benzamide 
• 1300747-70-9 methyl 3-methyl-2-(4-(4-nitrophenyl)thiazole-2-carboxamido)butanoate 
• 1300747-69-6 methyl 2-(4-(4-aminophenyl)thiazole-2-carboxamido)-3-methylbutanoate 
• 1300747-98-1 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoic acid 
• 1300747-97-0 methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate 

Relevant articles and documents

Design, synthesis, and biological evaluation of N,N-disubstituted-4-arylthiazole-2-methylamine derivatives as cholesteryl ester transfer inhibitors

Cholesteryl ester transfer protein (CETP) has been identified as a potential target for cardiovascular disease (CVD) for its important role in the reverse cholesteryl transfer (RCT) process. In our previous work, compound 5 was discovered as a moderate CETP inhibitor. The replacement of the amide linker by heterocyclic aromatics and then a series of N,N-substituted-4-arylthiazole-2-methylamine derivatives were designed by utilizing a conformational restriction strategy. Thirty-six compounds were synthesized and evaluated for their CETP inhibitory activities. Structure-activity relationship studies indicate that electron donor groups substituted ring A, and electron-withdrawing groups at the 4-position of ring B were critical for potency. Among these compounds, compound 30 exhibited excellent CETP inhibitory activity (IC50 = 0.79 ± 0.02 μM) in vitro and showed an acceptable metabolic stability.

Evaluation of thiazole containing biaryl analogs as diacylglycerol acyltransferase 1 (DGAT1) inhibitors

Biphenyl carboxylic acids, exemplified by compound 5, are known potent inhibitors of diacylglycerol acyltransferase, DGAT1, an enzyme involved in the final committed step of triglyceride biosynthesis. We have synthesized and evaluated 2-phenylthiazole, 4-

HETEROARYL COMPOUNDS AS DGAT-1 1NHIBITORS

The present invention relates to novel heteroaryl compounds, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or disorders mediated by Diacylglycerol acyltransferase (DGAT) enzyme, particularly DGAT- 1.