53242-88-9

Basic information

• Product Name: 4-(4-Chloro-benzyl)-2H-phthalazin-1-one
• Synonyms: 4-(4-chloro-benzyl)-2h-phthalazin-1-one;4-[(4-chlorophenyl)methyl]phthalazin-1(2h)-one;4-(4-Chlorobenzyl)-1,2-dihydrophthalazine-1-one;4-[(4-Chlorophenyl)methyl]-1(2H)-phthalazinone;4-(4-Chlorobenzyl)-1(2H)-phthalazinone;Azelastine Related CoMpound D;4-(4-Chlorobenzyl)phthalazin-1(2H)-one;Azelastine Impurity D(USP)
• CAS NO: 53242-88-9
• Molecular Formula: C₁₅H₁₁ClN₂O
• Molecular Weight: 270.71
• EINECS: 258-445-3
• Product Categories: Ketone;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 53242-88-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 206-207 °C(Solv: ethanol (64-17-5))
• Boiling Point: 522.3 °C at 760 mmHg
• Flash Point: 269.7 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 1.57E-11mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 12.08±0.40(Predicted)
• CAS DataBase Reference: 4-(4-Chloro-benzyl)-2H-phthalazin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Chloro-benzyl)-2H-phthalazin-1-one(53242-88-9)
• EPA Substance Registry System: 4-(4-Chloro-benzyl)-2H-phthalazin-1-one(53242-88-9)

Safety Data

• Hazardous Substances Data: 53242-88-9(Hazardous Substances Data)

Usage

Uses

Stilbene-related heterocyclic compound with anti-HIV activity. A potent vasorelaxant agent.

InChI:InChI=1/C15H11ClN2O/c16-11-7-5-10(6-8-11)9-14-12-3-1-2-4-13(12)15(19)18-17-14/h1-8H,9H2,(H,18,19)

Upstream product

• 20526-97-0 3-(4-chlorobenzylidene)-2-benzofuran-1(3H)-one 
• 53242-76-5 2‐(4-chlorophenylacetyl)benzoic acid 
• 105279-16-1 (Z)-3-(4-chlorophenyl)methylidenephthalide 
• 94801-28-2 (E)-3-(4-chlorobenzylidene)phthalide 
• 1878-66-6 4-chlorophenylacetic Acid 
• 85-44-9 phthalic anhydride 
• 2257-69-4 1-chloro-4-phthalazinone 
• 149923-10-4 (4-chlorobenzyl)zinc(II) chloride 
• 87-41-2 2-benzofuran-1(3H)-one 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 756415-37-9 4-(p-Chlorbenzyl)-2-<2-(N-methylpyrrolidin-2-yl)-ethyl>-1(2H)-phthalazinon 
• 58581-89-8 azelastine 
• 955359-78-1 1,1-dimethylethyl (2R)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate 
• 955359-80-5 1,1-dimethylethyl (2S)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate 
• 955359-87-2 1,1-dimethylethyl 4-[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]hexahydro-1H-azepine-1-carboxylate 
• 955360-43-7 4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone hydrochloride salt 
• 1279125-95-9 4-[(4-chlorophenyl)methyl]-2-(1-methyl-3-pirrolidinylmethyl)-1(2H)-phthalazinone 
• 181578-53-0 4-[(4-chlorophenyl)methyl]-2-{[(2S)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone 
• 955359-81-6 4-[(4-chlorophenyl)methyl]-2-{[(2S)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone 
• 955359-77-0 2-(2-aminoethyl)-4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone 
• 955360-36-8 4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-methoxyphenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone 
• 955360-37-9 4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-hydroxyphenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone 
• 955360-38-0 4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone 

Relevant articles and documents

PHENYL PHTHALAZINE DERIVATIVE, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a compound represented by Chemical Formula 1, or a pharmaceutically acceptable salt thereof. The compound according to the present invention can be usefully used for the prevention or treatment of cardiovascular diseases.

Microwave-promoted synthesis of some novel 4-(4-methyl-phenyl)-substituted phthalazin-1-one derivatives

In this study, a series of 4-(4-methyl-phenyl)-substituted phthalazin-1-one derivatives have been synthesized with the combination of rapid microwave synthesis and phasetransfer catalyst methodology, which is characterized by very short reaction times and easy workup procedures and which can be exploited to generate some novel phthalazinone heterocycles. Substituted phthalazin-1-one derivatives have been synthesized from phthalyl derivatives as starting material. The structures of these compounds were confirmed by NMR and mass spectral studies.

POTASSIUM CHANNEL MODULATORS

Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring Z1, R1, p, R3, and R4 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.