955359-78-1

Basic information

• Product Name: 1,1-dimethylethyl (2R)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate
• Synonyms: 1,1-dimethylethyl (2R)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate
• CAS NO: 955359-78-1
• Molecular Weight: 453.969
• Mol File: 955359-78-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,1-dimethylethyl (2R)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-dimethylethyl (2R)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate(955359-78-1)
• EPA Substance Registry System: 1,1-dimethylethyl (2R)-2-{[4-[(4-chlorophenyl)methyl]-1-oxo-2(1H)-phthalazinyl]methyl}-1-pyrrolidinecarboxylate(955359-78-1)

Safety Data

• Hazardous Substances Data: 955359-78-1(Hazardous Substances Data)

Upstream product

• 94801-28-2 (E)-3-(4-chlorobenzylidene)phthalide 
• 85-44-9 phthalic anhydride 
• 1878-66-6 4-chlorophenylacetic Acid 
• 53242-88-9 4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone 
• 59378-81-3 1-(tert-butoxycarbonyl)prolin-2R-ol 

Downstream Products

• 955360-43-7 4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone hydrochloride salt 
• 955359-72-5 GSK-1004723 
• 955360-33-5 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-methoxyphenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone 
• 955360-34-6 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-hydroxyphenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone 
• 955360-35-7 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone 

Relevant articles and documents

The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis

A series of potent phthalazinone-based human H1 and H 3 bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis, were identified. Blockade of H3 receptors is thought to improve efficacy on nasal congestion, a symptom of allergic rhinitis that is currently not treated by current antihistamines. Two analogues (56a and 56b) had slightly lower H1 potency (pA2 9.1 and 8.9, respectively, vs 9.7 for the clinical gold-standard azelastine, and H3 potency (pK i 9.6 and 9.5, respectively, vs 6.8 for azelastine). Compound 56a had longer duration of action than azelastine, low brain penetration, and low oral bioavailability, which coupled with the predicted low clinical dose, should limit the potential of engaging CNS-related side-effects associated with H 1 or H3 antagonism.

2-SUBSTITUTED 4-BENZYLPHTHALAZINONE DERIVATIVES AS HISTAMINE H1 AND H3 ANTAGONISTS

The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis.