5326-15-8

Basic information

• Product Name: (1E)-bis[1-(4-chlorophenyl)ethylidene]hydrazine
• CAS NO: 5326-15-8
• Molecular Formula: C₁₆H₁₄Cl₂N₂
• Molecular Weight: 305.2018
• Mol File: 5326-15-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 380.866°C at 760 mmHg
• Flash Point: 184.141°C
• Density: 1.176g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: (1E)-bis[1-(4-chlorophenyl)ethylidene]hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (1E)-bis[1-(4-chlorophenyl)ethylidene]hydrazine(5326-15-8)
• EPA Substance Registry System: (1E)-bis[1-(4-chlorophenyl)ethylidene]hydrazine(5326-15-8)

Safety Data

• Hazardous Substances Data: 5326-15-8(Hazardous Substances Data)

Usage

General Description

The chemical (1E)-bis[1-(4-chlorophenyl)ethylidene]hydrazine, also known as trans-bis(4-chlorophenyl)hydrazine, is a compound with the molecular formula C14H14Cl2N2. (1E)-bis[1-(4-chlorophenyl)ethylidene]hydrazine is an organic hydrazine derivative that consists of two 4-chlorophenyl groups attached to a central hydrazine moiety. It is commonly used in organic synthesis and chemical research as a building block for the preparation of various pharmaceuticals and agrochemicals. The compound may also have potential applications in the fields of materials science and catalysis. However, (1E)-bis[1-(4-chlorophenyl)ethylidene]hydrazine should be handled with care, as it may pose hazards if not used properly.

Upstream product

• 99-91-2 para-chloroacetophenone 
• 61185-76-0 1-(p-chlorophenyl)-1-diazoethane 
• 79881-23-5 t-butyl β-methyl-β-(p-chlorophenyl)glycidate 
• 56-23-5 tetrachloromethane 
• 40137-41-5 (1-(4-chlorophenyl)ethylidene)hydrazine 
• 3252-43-5 dibromoacetonitrile 
• 354-48-3 1,1,1-tribromotrifluoroethane 
• 1956-39-4 4-chloroacetophenone oxime 
• 75230-50-1 p-chloroacetophenone tosylhydrazone 

Downstream Products

• 90861-43-1 (E)-3-(4-Chloro-phenyl)-3-{N'-[1-(4-chloro-phenyl)-eth-(E)-ylidene]-hydrazino}-1-cyclohexyl-allylideneamine 
• 64620-62-8 α-Brom-p-chloracetophenonazin 
• 99-91-2 para-chloroacetophenone 
• 90861-72-6 1-Amino-6-(4-chloro-phenyl)-4-cyclohexyl-1H-pyrimidin-2-one 
• 90861-64-6 6-(4-Chloro-phenyl)-1-[1-(4-chloro-phenyl)-eth-(E)-ylideneamino]-4-cyclohexyl-1H-pyrimidin-2-one 
• 90861-57-7 [(E)-3-(4-Chloro-phenyl)-3-{N'-[1-(4-chloro-phenyl)-eth-(E)-ylidene]-hydrazino}-1-cyclohexyl-prop-2-en-(E)-ylidene]-carbamic acid ethyl ester 
• 1189947-92-9 C₂₀H₁₇Cl 
• 1189947-91-8 (4-chlorophenyl)(methyl)(3,5-xylyl)methane 
• 1198575-42-6 1-methyl-3,4-diphenyl-6-chloro-isoquinoline 

Relevant articles and documents

Palladium-Catalyzed Regioselective Acylation of Diazines with Toluenes: A New Approach to the Synthesis of ortho-Diacylbenzenes

A highly efficient and practical procedure for chemo- and regioselective synthesis of ortho-diacylbenzenes through Pd-catalyzed oxidative C–H bond activation has been developed. Using this method, a variety of ortho-diacylbenzenes were prepared in moderate to good yields, by direct acylation of diazines with toluene derivatives as acylation source. Ortho-diacylbenzenes may be used as precursors in synthesis of pharmaceuticals and agrochemicals.

Rapid and Atom Economic Synthesis of Isoquinolines and Isoquinolinones by C–H/N–N Activation Using a Homogeneous Recyclable Ruthenium Catalyst in PEG Media

Herein, we report an atom-efficient, rapid, green, and sustainable approach to synthesize isoquinolines and isoquinolinones using a homogeneous recyclable ruthenium catalyst in PEG Media assisted by microwave energy. Dibenzoylhydrazine was used for C–H/N–N activation reactions for the first time in combination with ketazine as oxidizing directing groups for annulation reactions with internal alkynes. The developed protocol is environmentally benign due to significantly shortened times with an easy extraction method, higher atom economy, external oxidant and silver or antimony salt free conditions, applicability to a gram scale synthesis, use of biodegradable solvent and wide substrate scope with higher product yields. Moreover, it is worth noting that the established methodology allowed reuse of the catalytic system for up to five successive runs with minimal loss in activity.

Tungsten hexachloride nanoparticles loaded on montmorillonite K-10: a novel solid acid catalyst in the synthesis of symmetrical and unsymmetrical azines

In the present investigation, we have developed a novel technique to prepare azines using nano-WCl6 loaded on Montmorillonite K10 clay as a highly active catalyst. A variety of aldehydes and ketones were efficiently converted to the corresponding azines using catalytic amounts of nanosized WCl6/Mont. K10 under mild conditions. The nanostructures of WCl6 loaded on Mont. K10 as solid acid catalyst have been prepared by solid dispersion method. The advantages of this catalyst are rapid completion of the reactions, simplicity of performance, lack of pollution and mild and green reaction conditions. The morphologies, structure, and chemical components of parent and modified clay were successfully characterized using SEM, FT-IR, CV, XRD and EDX measurements.