53314-17-3

Basic information

• Product Name: 2-(4-CHLOROPHENYL)-5-METHYL-1H-BENZO[D]IMIDAZOLE
• Synonyms: 2-(4-CHLOROPHENYL)-5-METHYL-1H-BENZO[D]IMIDAZOLE;2-(4-Chlorophenyl)-5-methyl-1H-benzoimidazole;2-(4-Chlorophenyl)-5-MethylbenziMidazole, 95%;2-(4-chlorophenyl)-6-methyl-1H-benzimidazole
• CAS NO: 53314-17-3
• Molecular Formula: C₁₄H₁₁ClN₂
• Molecular Weight: 242.7
• Mol File: 53314-17-3.mol
• Article Data: 42

Chemical Properties

• Melting Point: 224-225 °C
• Boiling Point: 431.2±47.0 °C(Predicted)
• Appearance: /
• Density: 1.286±0.06 g/cm3(Predicted)
• PKA: 11.28±0.10(Predicted)
• CAS DataBase Reference: 2-(4-CHLOROPHENYL)-5-METHYL-1H-BENZO[D]IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENYL)-5-METHYL-1H-BENZO[D]IMIDAZOLE(53314-17-3)
• EPA Substance Registry System: 2-(4-CHLOROPHENYL)-5-METHYL-1H-BENZO[D]IMIDAZOLE(53314-17-3)

Safety Data

• Hazardous Substances Data: 53314-17-3(Hazardous Substances Data)

Usage

General Description

The chemical 2-(4-chlorophenyl)-5-methyl-1H-benzo[d]imidazole is a heterocyclic compound with a benzimidazole core structure. It contains a 4-chlorophenyl group and a methyl group, both of which are attached to the benzimidazole ring. This chemical compound has potential pharmacological and biological activities, and may be used in drug discovery and development. Studies have shown that benzimidazole derivatives have a wide range of biological activities, including antimicrobial, antiviral, antitumor, and anti-inflammatory properties, making this compound of interest for further research and potential applications in the pharmaceutical industry.

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Relevant articles and documents

Selective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite

Earth abundant metals are much less expensive, promising, valuable metals and could be served as catalysts for the borrowing hydrogen reaction, dehydrogenation and heterocycles synthesis, instead of noble metals. The uniformly dispersed zinc composites were designed, synthesized and carefully characterized by means of XPS, EDS, TEM and XRD. The resulting zinc composite showed good catalytic activity for the N-alkylation of amines with amines, ketones with alcohols in water under base-free conditions, while unsaturated carbonyl compounds could also be synthesized by tuning the reaction conditions. Importantly, it was the first time to realize the synthesis of 2-aryl-1H-benzo[d]imidazole derivatives by using this zinc composite under green conditions. Meanwhile, this zinc catalyst could be easily recovered and reused for at least five times.

Copper-Mediated Diamination of Arylboronic Acids for the Synthesis of 2-Aryl Benzimidazoles Using Trimethylsilyl Azide as the Amino Sources with Aldehydes

A direct and versatile copper-mediated three-component reaction of arylboronic acids, trimethylsilyl azide and aldehydes for the synthesis of benzimidazoles is reported. The reaction is well tolerated by a wide range of substituted aromatic aldehydes and aromatic boronic acids to produce the corresponding benzimidazoles in moderate to high yields. Mechanism investigations demonstrated that copper-promoted Chan-Evans-Lam coupling, C?H amination, and oxidative cycloaddition are involved in the tandem processes. (Figure presented.).

tert-Butyl nitrite catalyzed synthesis of benzimidazoles from o-phenylenediamine and aldehydes at room temperature

A simple and efficient method is demonstrated for the synthesis of benzimidazoles via cyclocondensation of o-phenylenediamine with aldehydes in the presence of catalytic amount of tert-butyl nitrite. All the reactions were carried out at room temperature while the desired products were obtained in good to excellent yields.