5338-44-3Relevant articles and documents
Direct para-Selective C-H Amination of Iodobenzenes: Highly Efficient Approach for the Synthesis of Diarylamines
Chen, Yujie,Huang, Zhibin,Jiang, Yaqiqi,Shu, Sai,Yang, Shan,Shi, Da-Qing,Zhao, Yingsheng
, p. 8226 - 8235 (2021/06/28)
Iodine(III)-mediated synthesis of 4-iodo-N-phenylaniline from iodobenzene has been achieved, and the reaction can proceed under mild conditions. A variety of functional groups were well tolerated, providing the corresponding products in moderate to good yields. The remaining iodine group provides an effective platform for converting the products into several valuable asymmetric diphenylamines. Most importantly, this reaction can be easily scaled up to the ten-gram scale, highlighting its synthetic utility. The mechanistic study revealed that the in situ generated aryl hypervalent iodine intermediate is the key factor to realize this para-selective C-H amination reaction.
Utilization of ultrasonic as an approach of green chemistry for synthesis of hydrazones and bishydrazones as potential antimicrobial agents
Younis, Ahmed,Awad, Ghada E. A.
, p. 599 - 610 (2020/05/28)
Hydrazides 3,4, Hydrazones 6a-c, bishydrazones 8a,b, N-hydroxy-N'- arylpropanehydrazonamide 9a,b and 1-(piperidin-1-yl)-N2-arylamidrazones 10a,b were prepared under ultrasonic waves as an approach for green chemistry. a notable good yield and short reaction time were afforded under ultrasonic waves.The structures of compounds were confirmed in terms of spectroscopic and elemental analyses. The invitro antimicrobial activity of the prepared compounds were evaluated. most of compounds exhibited an excellent growth inhibition such as compounds 2, 3 and 8b against gram positive bacteria, while 2, 3, 8b, 9a, 10a and 10b against gram negative bacteria. all of tested compounds have excellent or good antifungal activity except 3.
Synthesis of acetamides from aryl amines and acetonitrile by diazotization under metal-free conditions
Duan, Pan,Guo, Yu,Kang, Huan,Li, Yi-Na,Wen, Xianghao,Xiao, Fang,Zeng, Yao-Fu,Zhang, Na-Na
supporting information, p. 2169 - 2172 (2019/11/25)
An efficient and metal-free coupling reaction has been developed that affords acetamides from the corresponding aryl amines and acetonitrile. This method tolerates a wide range of functional groups and is selective toward aryl amines. Preliminary mechanistic studies were conducted.
