53518-16-4Relevant articles and documents
Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)- 2H-pyrano[3,2-g]quinolin-2-one
Edwards, James P.,Higuchi, Robert I.,Winn, David T.,Pooley, Charlotte L. F.,Caferro, Thomas R.,Hamann, Lawrence G.,Zhi, Lin,Marschke, Keith B.,Goldman, Mark E.,Jones, Todd K.
, p. 1003 - 1008 (2007/10/03)
A series of 2H-pyrano[3,2-g]quinolin-2-ones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2H-pyrano[3,2- g]quinolin-2-one, displayed moderate