53538-13-9

Basic information

• Product Name: Apigenin 7-O-methylglucuronide
• Synonyms: Apigenin 7-O-methylglucuronide;(2S,3S,4S,5R,6S)-Methyl 3,4,5-trihydroxy-6-((5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chroMen-7-yl)oxy)tetrahydro-2H-pyran-2-carboxylate
• CAS NO: 53538-13-9
• Molecular Formula: C₂₂H₂₀O₁₁
• Molecular Weight: 446
• Mol File: 53538-13-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Apigenin 7-O-methylglucuronide(CAS DataBase Reference)
• NIST Chemistry Reference: Apigenin 7-O-methylglucuronide(53538-13-9)
• EPA Substance Registry System: Apigenin 7-O-methylglucuronide(53538-13-9)

Safety Data

• Hazardous Substances Data: 53538-13-9(Hazardous Substances Data)

Usage

General Description

Apigenin 7-O-methylglucuronide is a naturally occurring chemical compound found in plants such as parsley, celery, and chamomile. It is a flavonoid and a derivative of apigenin, a bioactive compound known for its antioxidant and anti-inflammatory properties. Apigenin 7-O-methylglucuronide is formed when apigenin undergoes methylation and glucuronidation in the body. It has been studied for its potential role in preventing and treating various health conditions including cancer, cardiovascular diseases, and neurodegenerative disorders. Additionally, it has been shown to have anti-cancer properties by inhibiting tumor growth and promoting apoptosis in cancer cells. Overall, Apigenin 7-O-methylglucuronide has demonstrated promising health benefits and is the subject of ongoing research for its potential therapeutic uses.

Upstream product

• 67-56-1 methanol 
• 29741-09-1 apigenin-7-O-β-D-glucuronide 
• 34340-20-0 5,4'-diacetoxyflavone-7-O-D-triacetoxyglucuronic acid methyl ester 
• 520-36-5 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 
• 3316-46-9 apigenin triacetate 

Downstream Products

• 29741-09-1 apigenin-7-O-β-D-glucuronide 

Relevant articles and documents

A 5, 4' - dihydroxy flavone - 7 - O - D - glucuronic acid preparation method

The invention relates to the drug synthesis technical field, and in particular, relates to a preparation method of 5,4'-dihydroxy flavone-7-O-D-glucuronic acid. The method comprises the following steps: taking a compound having a structure represented by the formula II, and under an alkaline condition, acylating to obtain a compound having a structure represented by the formula III; taking the compound having the structure represented by the formula III and alpha-bromo triacetoxy methyl glucuronate, and carrying out a glycosylation reaction, to obtain a compound having a structure represented by the formula IV; taking the compound having the structure represented by the formula IV, and hydrolyzing under an acidic condition, to obtain a compound having a structure represented by the formula V; and taking the compound having the structure represented by the formula V, hydrolyzing under an alkaline condition, and thus obtaining the product. The method provided by the invention has the advantages of cheap and easily obtained starting raw materials, less reaction steps, and simple and easily operated process, and is suitable for large-scale industrialized production; and through testing, the purity of the obtained product can reach more than 98%, and the total yield reaches up to 56%.