53573-33-4

Basic information

• Product Name: Benzenepropanethioic acid, S-phenyl ester
• CAS NO: 53573-33-4
• Molecular Formula: C15H14OS
• Molecular Weight: 242.342
• Mol File: 53573-33-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzenepropanethioic acid, S-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanethioic acid, S-phenyl ester(53573-33-4)
• EPA Substance Registry System: Benzenepropanethioic acid, S-phenyl ester(53573-33-4)

Safety Data

• Hazardous Substances Data: 53573-33-4(Hazardous Substances Data)

Upstream product

• 108-98-5 thiophenol 
• 501-52-0 3-Phenylpropionic acid 
• 4551-15-9 phenylthiotrimethylsilane 
• 21273-15-4 trimethylsilyl ester of hydrocinnamic acid 
• 111171-84-7 4-phenyl-1,1,1-tris(phenylthio)butane 
• 645-45-4 hydrocinnamic acid chloride 
• 104-53-0 3-phenyl-propionaldehyde 
• 882-33-7 diphenyldisulfane 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 
• 97723-86-9 3-phenylthiopropionic acid S-4-chlorophenyl ester 
• 23522-73-8 3-phenylpropionic acid 4-chlorophenyl ester 
• 4119-41-9 1-iodo-3-phenylpropan 

Downstream Products

• 1052108-49-2 C₂₁H₂₄O₂S 
• 144914-78-3 1-(trimethylsilyl)-3-phenylpentan-1,4-dione 
• 66132-93-2 1-trimethylsilyl-3-phenyl-2-phenylsulphinylpropan-1-one 
• 66132-89-6 trimethyl<2-(phenylthio)-3-phenylpropanoyl>silane 
• 63578-13-2 1-(trimethylsilyl)-3-phenyl-1-(trimethylsiloxy)-1-propene 
• 66132-97-6 2-trimethylsilyl-4-phenyl-1-oxa-1,3-butadiene 
• 68117-68-0 3-phenyl-1-phenylsulphenyl-1-trimethylsiloxypropene 

Relevant articles and documents

Palladium-Catalyzed Thiocarbonylations with Triisopropylsilyl Thioethers

We have developed a palladium-catalyzed thiocarbonylation through the reaction of a σ-alkyl palladium intermediate with carbon monoxide and a triisopropylsilyl (TIPS) thioether. The use of CsF, (IPr)Pd(allyl)Cl [IPr =1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene], CO, and a TIPS thioether in THF are key to obtaining alkyl and aryl thioesters in high yields. The yield of the palladium-catalyzed thiocarbonylation depended on the structure of the substrate; indoline-2-one derivatives were formed faster than indoline derivatives. The reactions of benzoyl and hydrocinnamoyl fluorides with TIPSSPh and CsF also gave the corresponding thioesters.

Palladium-catalyzed thiocarbonylation of alkenes toward linear thioesters

Thiocarbonylation of alkenes offers an ideal procedure for the synthesis of thioesters. However, thiocarbonylation of alkenes, especially styrenes, to produce valuable linear thioesters has remained a challenge. In this Letter, a general palladium-catalyz

Comprehensive Study of the Organic-Solvent-Free CDI-Mediated Acylation of Various Nucleophiles by Mechanochemistry

Acylation reactions are ubiquitous in the synthesis of natural products and biologically active compounds. Unfortunately, these reactions often require the use of large quantities of volatile and/or toxic solvents, either for the reaction, purification or isolation of the products. Herein we describe and discuss the possibility of completely eliminating the use of organic solvents for the synthesis, purification and isolation of products resulting from the acylation of amines and other nucleophiles. Thus, utilisation of N,N′-carbonyldiimidazole (CDI) allows efficient coupling between carboxylic acids and various nucleophiles under solvent-free mechanical agitation, and water-assisted grinding enables both the purification and isolation of pure products. Critical parameters such as the physical state and water solubility of the products, milling material, type of agitation (vibratory or planetary) as well as contamination from wear are analysed and discussed. In addition, original organic-solvent-free conditions are proposed to overcome the limitations of this approach. The calculations of various green metrics are included, highlighting the particularly low environmental impact of this strategy.