536-32-3

Basic information

• Product Name: 2-Hydroxy-4-isopropylbenzaldehyde
• Synonyms: 2-Hydroxy-4-isopropylbenzaldehyde;4-Isopropylsalicylaldehyde
• CAS NO: 536-32-3
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• Mol File: 536-32-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 265.45°C at 760 mmHg
• Flash Point: 110.376°C
• Appearance: /
• Density: 1.098g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.24±0.10(Predicted)
• CAS DataBase Reference: 2-Hydroxy-4-isopropylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-4-isopropylbenzaldehyde(536-32-3)
• EPA Substance Registry System: 2-Hydroxy-4-isopropylbenzaldehyde(536-32-3)

Safety Data

• Hazardous Substances Data: 536-32-3(Hazardous Substances Data)

Usage

Uses

4-Isopropylsalicylaldehyde is a potent partial tyrosinase inhibitor.

InChI:InChI=1/C10H12O2/c1-7(2)8-3-4-9(6-11)10(12)5-8/h3-7,12H,1-2H3

Upstream product

• 618-45-1 3-isopropylhydroxybenzene 
• 181035-65-4 4-isopropyl-2-methoxy-benzaldehyde 
• 6380-20-7 3-isopropylanisole 
• 100-97-0 hexamethylenetetramine 
• 50-00-0 formaldehyd 
• 122-03-2 (4-isopropylbenzaldehyde) 

Downstream Products

• 181035-65-4 4-isopropyl-2-methoxy-benzaldehyde 
• 409359-17-7 2-benzyloxy-4-isopropylbenzaldehyde 

Relevant articles and documents

Phosphine-Catalyzed [3+2] Annulation of β-Sulfonamido-Substituted Enones with Sulfamate-Derived Cyclic Imines

Phosphine-catalyzed [3+2] annulation of β-sulfonamido-substituted enones and sulfamate-derived cyclic imines has been developed, giving a series of imidazoline derivatives in moderate to excellent yields with good to excellent diastereoselectivities. A scale-up reaction worked well under mild reaction conditions. A possible mechanism was proposed on the basis of the results obtained.

Aldehyde-Assisted Ruthenium(II)-Catalyzed C-H Oxygenations

Versatile ruthenium(II) complexes allow for site-selective C-H oxygenations with weakly-coordinating aldehydes. The challenging C-H functionalizations proceed with high chemoselectivity by rate-determining C-H metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.

CHROMENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (I). Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.