53654-70-9

Basic information

• Product Name: N-(4-Chlorobenzyl)ethane-1,2-diamine
• Synonyms: N-(4-Chlorobenzyl)ethane-1,2-diamine;N1-(4-chlorobenzyl)ethane-1,2-diamine
• CAS NO: 53654-70-9
• Molecular Formula: C₉H₁₃ClN₂
• Molecular Weight: 184.66592
• Mol File: 53654-70-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-Chlorobenzyl)ethane-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Chlorobenzyl)ethane-1,2-diamine(53654-70-9)
• EPA Substance Registry System: N-(4-Chlorobenzyl)ethane-1,2-diamine(53654-70-9)

Safety Data

• Hazardous Substances Data: 53654-70-9(Hazardous Substances Data)

Upstream product

• 60434-95-9 N,N'-bis(4-chlorobenzylidene)ethane-1,2-diamine 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 107-15-3 ethylenediamine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 69840-61-5 2-chloro-5-((2-(nitromethylene)imidazolidine-1-yl)methyl)benzene 
• 1348916-88-0 C₂₂H₂₄ClN₅O₄ 
• 1348334-17-7 C₂₂H₂₄ClN₅O₃ 
• 1349889-00-4 C₂₃H₂₆ClN₅O₃ 
• 1348964-49-7 C₂₅H₃₀ClN₅O₃ 
• 1350121-36-6 C₂₄H₂₈ClN₅O₃ 
• 1341126-78-0 2-(4-chlorobenzyl)-1,2,5-thiadiazolidine 1,1-dioxide 

Relevant articles and documents

Design, Synthesis, and Synergistic Activity of Eight-Membered Oxabridge Neonicotinoid Analogues

Insecticide synergists are sought-after due to their potential in improving the pesticide control efficacy with a reduced dose of an active ingredient. We previously reported that a cis-configuration neonicotinoid (IPPA08) exhibited specific synergistic activity toward neonicotinoid insecticides. In this study, we synthesized a series of structural analogues of IPPA08 by converting the pyridyl moiety of IPPA08 into phenyl groups, via facile double-Mannich condensation reactions between nitromethylene compounds and glutaraldehyde. All of the oxabridged neonicotinoid compounds were found to increase the toxicity of imidacloprid against Aphis craccivora. Notably, compound 25 at 0.75 mg/L lowered the LC50 value of imidacloprid against A. craccivora by 6.54-fold, while a 3.50-fold reduction of the LC50 value was observed for IPPA08. The results of bee toxicity test showed that compound 25 display selectivity in its effects on imidacloprid toxicity against the honey bee (Apis mellifera L.). In summary, replacing the pyridyl ring with a phenyl ring was a viable approach to obtain a novel synergist with oxabridged moiety for neonicotinoid insecticides.

Potent inhibition of Norwalk virus by cyclic sulfamide derivatives

A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold has been identified. The structure of the initial hit (compound 2a, ED50 4 μM, TD50 50 μM) has been prospected by exploiting multiple points of diversity and generating appropriate structure-activity relationships.