53750-65-5

Basic information

• Product Name: 3-Pyridinecarbonyl chloride, 2-methoxy- (9CI)
• Synonyms: 3-Pyridinecarbonyl chloride, 2-methoxy- (9CI);2-Methoxypyridine-3-carbonyl chloride
• CAS NO: 53750-65-5
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58104
• Product Categories: ACIDHALIDE
• Mol File: 53750-65-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 258.1±20.0 °C(Predicted)
• Appearance: /
• Density: 1.289±0.06 g/cm3(Predicted)
• PKA: 0.80±0.10(Predicted)
• CAS DataBase Reference: 3-Pyridinecarbonyl chloride, 2-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonyl chloride, 2-methoxy- (9CI)(53750-65-5)
• EPA Substance Registry System: 3-Pyridinecarbonyl chloride, 2-methoxy- (9CI)(53750-65-5)

Safety Data

• Hazardous Substances Data: 53750-65-5(Hazardous Substances Data)

Upstream product

• 16498-81-0 2-methoxynicotinic acid 

Downstream Products

• 100948-48-9 2-Methoxy-N-phenethyl-nicotinamide 
• 100948-45-6 4-<2-<(2-methoxynicotinoyl)amino>ethyl>benzaldehyde 
• 100947-30-6 5-(4-{2-[(2-methoxynicotinoyl)amino]ethyl}phenyl)oxazolidine-2,4-dione 
• 233755-12-9 methyl 4-(4-methoxybenzenesulfonyl)-1-(2-methoxypyridinyl-3-carbonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate 
• 1021901-78-9 C₁₉H₂₃N₃O₂ 
• 1021188-94-2 C₁₈H₂₃N₃O₂ 
• 1021188-96-4 C₁₉H₂₃N₃O₃ 
• 1076689-99-0 2-methoxy-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] nicotinanilide 
• 1026106-35-3 C₂₉H₂₉N₃O₅ 
• 1021901-41-6 C₃₃H₃₅N₃O₅ 
• 1021901-40-5 C₃₃H₃₅N₃O₅ 
• 1021901-31-4 C₃₃H₃₆N₄O₆ 
• 7145-28-0 2-methoxy-3-pyridinecarboxamide 

Relevant articles and documents

PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6

Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R4, R5, R8, R10, R11, X1, X2, X3, X9, X12, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.

SUBSTITUTED IMIDAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, and G are defined herein.

Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: Synthesis and CRAC channel inhibitory activity of 4′-[(trifluoromethyl)pyrazol-1-yl]carboxanilides

From a series of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides derived from 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide, one inhibited thapsigargin-induced Ca2+ influx in Jurkat T cells (IC50 = 77 nM) and exhibited high selectivity for the CRAC channel over the VOC channel (index: >130). Another acted as an inhibitor for both T lymphocyte activation-induced diseases and ovalbumin-induced airway eosinophilia in rats (ED50 = 1.3 mg/kg) p.o.