7145-28-0

Basic information

• Product Name: 2-METHOXYNICOTINAMIDE
• Synonyms: 2-METHOXYNICOTINAMIDE;Nsc74202;2-Methoxypyridine-3-carboxamide
• CAS NO: 7145-28-0
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15062
• Mol File: 7145-28-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 295 °C at 760 mmHg
• Flash Point: 132.2 °C
• Appearance: /
• Density: 1.213 g/cm³
• Vapor Pressure: 0.00157mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 2-METHOXYNICOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXYNICOTINAMIDE(7145-28-0)
• EPA Substance Registry System: 2-METHOXYNICOTINAMIDE(7145-28-0)

Safety Data

• Hazardous Substances Data: 7145-28-0(Hazardous Substances Data)

Usage

General Description

2-Methoxynicotinamide is a chemical compound with the molecular formula C7H8N2O2. It is a derivative of nicotinamide, an important vitamin and coenzyme involved in various metabolic processes. 2-Methoxynicotinamide has been studied for its potential therapeutic properties, including its role in protecting against oxidative stress and inflammation. It has also shown promise in the treatment of various diseases, such as diabetes and neurodegenerative disorders. Research on 2-Methoxynicotinamide is ongoing and its potential applications in medicine and biotechnology continue to be explored.

InChI:InChI=1/C7H8N2O2/c1-11-7-5(6(8)10)3-2-4-9-7/h2-4H,1H3,(H2,8,10)

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 7254-34-4 2-methoxy-3-cyanopyridine 
• 67-56-1 methanol 
• 98-92-0 nicotinamide 
• 16498-81-0 2-methoxynicotinic acid 
• 53750-65-5 2-methoxypyridine-3-carbonyl chloride 

Downstream Products

• 20265-38-7 3-amino-2-methoxypyridine 

Relevant articles and documents

PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6

Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R4, R5, R8, R10, R11, X1, X2, X3, X9, X12, and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.

8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS

Provided herein are 8-substituted quinolines and related analogues as sirtuin-modulating compounds of Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

SIMULTANEOUS PARTICIPATION OF SEVERAL EXCITED STATES IN PHOTOCHEMICAL METHOXYLATION AND METHYLATION OF 3-PYRIDINECARBOXAMIDE IN METHANOL

The UV-irradiation of 3-pyridinecarboxamide in methanol in the presence of sulfuric acid brings about methoxylation (ionic reaction) at the 2- and 6-position and methylation (radical reaction) at the 4- and 6-position.The effects of quenchers indicate that two methylation products originate from one excited triplet state which is quenched by energy transfer mechanism and that two methoxylation products originate from two different excited singlet states which are quenched by electron transfer mechanism.