538-60-3 Usage
Description
Dibenzyl Phosphite, also known as Dibenzyl Hydrogen Phosphate (CAS# 538-60-3), is a light yellow oil compound with significant utility in the field of organic synthesis. It is characterized by its chemical structure, which features a central phosphite group bonded to two benzyl groups, providing it with unique reactivity and properties that make it valuable for various applications.
Uses
Used in Organic Synthesis:
Dibenzyl Phosphite is used as a reagent in organic synthesis for its ability to facilitate a range of chemical reactions. Its phosphite group can act as a nucleophile, participating in reactions such as substitution, addition, and elimination processes. This versatility makes it a valuable component in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals.
Used in Chemical Research:
In the field of chemical research, Dibenzyl Phosphite is employed as a model compound to study the reactivity and properties of phosphite-containing molecules. Its well-defined structure and readily accessible synthesis make it an ideal candidate for investigating the fundamental aspects of phosphite chemistry, which can contribute to the development of new synthetic methods and applications.
Used in Flame Retardants:
Dibenzyl Phosphite is also used as an additive in the plastics and polymer industry, where it serves as a flame retardant. The phosphite group in the molecule can promote char formation and reduce the flammability of materials, making it a valuable component in the development of safer and more fire-resistant plastics and polymers.
Used in Lubricant Additives:
In the lubricant industry, Dibenzyl Phosphite is utilized as an additive to enhance the performance of lubricants. Its phosphite group can act as an anti-wear and extreme pressure agent, improving the load-carrying capacity and reducing wear in various mechanical systems. This application helps to extend the life of machinery and reduce maintenance costs.
Used in Catalysts:
Dibenzyl Phosphite is also employed in the development of catalysts for various industrial processes. Its unique chemical properties allow it to act as a catalyst or a catalyst precursor, facilitating reactions that are otherwise difficult or slow to occur. This application can lead to more efficient and environmentally friendly processes in the chemical, pharmaceutical, and materials industries.
Check Digit Verification of cas no
The CAS Registry Mumber 538-60-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 538-60:
(5*5)+(4*3)+(3*8)+(2*6)+(1*0)=73
73 % 10 = 3
So 538-60-3 is a valid CAS Registry Number.
538-60-3Relevant articles and documents
Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
Yan, Jun,Chen, Jie,Zhang, Shun,Hu, Jinhui,Huang, Ling,Li, Xingshu
, p. 5264 - 5283 (2016/07/06)
Twenty-nine novel indole-chalcone derivatives were synthesized and evaluated for antiproliferative activity. Among them, 14k exhibited most potent activity, with IC50 values of 3-9 nM against six cancer cells, which displayed a 3.8-8.7-fold increase in activity when compare with compound 2. Further investigation revealed 14k was a novel tubulin polymerization inhibitor binding to the colchicine site. Its low cytotoxicity toward normal human cells and nearly equally potent activity against drug-resistant cells revealed the possibility for cancer therapy. Cellular mechanism studies elucidated 14k arrests cell cycle at G2/M phase and induces apoptosis along with the decrease of mitochondrial membrane potential. Furthermore, good metabolic stability of 14k was observed in mouse liver microsomes. Importantly, 14k and its phosphate salt 14k-P inhibited tumor growth in xenograft models in vivo without apparent toxicity, which was better than the reference compound CA-4P and 2. In summary, 14k deserves consideration for cancer therapy.
Method and compositions for identifying anti-HIV therapeutic compounds
-
, (2008/06/13)
Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
Selective phosphorylation on primary alcohols of unprotected polyols
Ladame, Sylvain,Claustre, Samantha,Willson, Michele
, p. 37 - 47 (2007/10/03)
The triad tribenzylphosphite-iodine-pyridine offers a general selective method for phosphorylation reactions of primary alcohols of unprotected α-diols and polyols. A mechanistic study by 31P NMR allowed to evidence the formation, from iododibenzyl phosphate and pyridine, of a very reactive pyridinium salt intermediate. This analysis shows that pyridine behaves as a covalent catalyst like DMAP in acylation reactions from acylchloride. Due to its steric hindrance and high reactivity, this species appears to be the efficient selective phosphorylation reagent but leads to dibenzylphosphoric esters. Under mild conditions, the cleavage of benzyl groups gives monoester phosphoric acid.
