53839-60-4

Basic information

• Product Name: Retinoyl chloride
• Synonyms: Retinoyl chloride;OBWAFSRXIGEEKA-YCNIQYBTSA-N
• CAS NO: 53839-60-4
• Molecular Formula: C₂₀H₂₇ClO
• Molecular Weight: 318.88078
• EINECS: -0
• Mol File: 53839-60-4.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Retinoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Retinoyl chloride(53839-60-4)
• EPA Substance Registry System: Retinoyl chloride(53839-60-4)

Safety Data

• Hazardous Substances Data: 53839-60-4(Hazardous Substances Data)

Usage

Description

Retinoyl chloride is a chemical compound derived from vitamin A, specifically from the conversion of retinoic acid. It is a colorless to pale yellow crystalline solid that is soluble in organic solvents. Retinoyl chloride plays a crucial role in the synthesis of various pharmaceuticals and cosmetic ingredients due to its reactivity and ability to form esters.

Uses

Used in Pharmaceutical Industry:
Retinoyl chloride is used as an intermediate in the synthesis of retinyl ascorbate (RA-AsA) for the purpose of treating skin damage resulting from UV-induced production of free radicals. RA-AsA is a co-drug that combines the benefits of vitamin A and vitamin C, offering enhanced antioxidant and skin protective properties.
Used in Cosmetic Industry:
Retinoyl chloride is also used as a precursor in the production of cosmetic ingredients, such as retinyl esters, which are known for their anti-aging and skin rejuvenation properties. These esters are more stable and less irritating than retinoic acid, making them suitable for use in skincare products.

Upstream product

• 302-79-4 all-trans-retinoic-acid 
• 186581-53-3 diazomethane 
• 98300-76-6 2,3,4,6-tetra-O-acetylglucopyranosyl 1-amine 
• 7664-93-9 sulfuric acid 
• 1126-81-4 4-acetamidothiophenol 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 302-79-4 9-cis-retinoic acid 
• 7719-12-2 phosphorus trichloride 
• 60-29-7 diethyl ether 
• 57-88-5 cholesterol 

Downstream Products

• 65646-90-4 N-n-Propyl all-trans-retinamide 
• 85551-23-1 (2E,4E,6E,8E)-N-(2,3-dihydroxypropyl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamide 
• 110683-04-0 N-(all-trans-retinoyl)-L-alanine ethyl ester 
• 110683-01-7 N-(all-trans-retinoyl)-DL-leucine methyl ester 
• 110683-08-4 N-(all-trans-retinoyl)glutamic acid diethyl ester 
• 138752-02-0 all-(E)-retinoic and 13-(Z)-retinoic anhydride 
• 58175-89-6 retinoic anhydride 
• 110683-03-9 N-(all-trans-retinoyl)-L-phenylalanine methyl ester 
• 110683-06-2 N-(all-trans-retinoyl)-DL-tyrosine ethyl ester 
• 125780-97-4 3'-azido-3'-deoxy-5'-O-retinoylthimidine 
• 158419-87-5 (2,3,4-Tri-O-acetyl-β-D-xylopyranosyl)-4-retinamidophenylmethane 
• 158419-78-4 1-(2,3,4-Tri-O-acetyl-β-D-xylopyranosyl)-4-retinamidobenzene 
• 158419-74-0 1-(Methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate)-4-retinamidobenzene 
• 158419-85-3 (Methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosyluronate)-4-retinamidophenylmethane 

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