53885-46-4

Basic information

• Product Name: 5-(2-fluoro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine
• Synonyms: 5-(2-fluoro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine
• CAS NO: 53885-46-4
• Molecular Weight: 247.336
• Mol File: 53885-46-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(2-fluoro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-fluoro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine(53885-46-4)
• EPA Substance Registry System: 5-(2-fluoro-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine(53885-46-4)

Safety Data

• Hazardous Substances Data: 53885-46-4(Hazardous Substances Data)

Upstream product

• 272-14-0 thieno[3,2-c]pyridine 
• 345-35-7 2-fluorobenzyl chloride 
• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 446-48-0 o-fluorobenzyl bromide 
• 50-00-0 formaldehyd 

Downstream Products

• 150322-43-3 prasugel 
• 150322-38-6 5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one 

Relevant articles and documents

Method for preparing prasugrel intermediate

The invention discloses a method for preparing a prasugrel intermediate 5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-1,4,5,6,7,7a-hexahydrothieno[3,2-c]pyridine. The method comprises a following reaction route. As a result of experiments, the method provided by the invention has the advantages of simple operation, mild reaction conditions, low requirement on equipment, inexpensive and easy-to-obtain raw materials, high yield, and low production cost. An adopted solvent can synchronously recovered. The method can be easily applied in large-scale productions. The method meets the requirements of prasugrel industrialized production, and has industrial application value.