5409-52-9 Usage
Description
1-(4-chlorophenyl)-3-(diethylamino)propan-1-one, commonly known as 4-Chloro-α,α-diethylphenylacetone or 4-CEC, is a synthetic stimulant belonging to the cathinone class. It is recognized for its potent action as a serotonin-norepinephrine-dopamine reuptake inhibitor, which leads to its psychoactive effects. 1-(4-chlorophenyl)-3-(diethylamino)propan-1-one is often encountered in the form of a research chemical or designer drug and is not sanctioned for human consumption due to its potential for abuse and associated health risks. As a result, it is classified as a controlled substance and is illegal in numerous countries.
Uses
Used in Research Chemicals:
1-(4-chlorophenyl)-3-(diethylamino)propan-1-one is used as a research chemical for the study of its psychoactive properties and potential effects on the central nervous system. Its role as a serotonin-norepinephrine-dopamine reuptake inhibitor makes it a subject of interest for scientific research aimed at understanding the mechanisms of action and potential therapeutic applications related to mood and stimulant effects.
Used in Designer Drugs:
Although not intended for human consumption, 1-(4-chlorophenyl)-3-(diethylamino)propan-1-one is sometimes found as an ingredient in designer drugs, which are synthetic substances that mimic the effects of controlled substances. These designer drugs are often created to circumvent drug laws and are associated with significant health risks due to their unpredictable nature and potential for abuse.
Check Digit Verification of cas no
The CAS Registry Mumber 5409-52-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,0 and 9 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5409-52:
(6*5)+(5*4)+(4*0)+(3*9)+(2*5)+(1*2)=89
89 % 10 = 9
So 5409-52-9 is a valid CAS Registry Number.
5409-52-9Relevant articles and documents
Isochromanone-based urotensin-II receptor agonists
Lehmann, Fredrik,Currier, Erika A.,Olsson, Roger,Hacksell, Uli,Luthman, Kristina
, p. 3057 - 3068 (2007/10/03)
A series of analogues of the selective non-peptide urotensin II (UII) receptor agonist 3-(4-chlorophenyl)-3-(2-dimethylaminoethyl)-isochroman-1-one (AC-7954, 1) was synthesized and evaluated for UII agonist activity using a functional cell-based assay. The introduction of a methyl group in the 4-position resulted in a complete loss of activity, whereas substituents in the aromatic rings were beneficial. Sterically demanding amino groups were also detrimental to the activity. Several potent agonists were identified, six compounds being equally or more potent than 1. The most potent compound in the series was the 6,7-dimethyl analogue of 1 (16, pEC50 6.87). The racemate of 16 was resolved into the pure enantiomers using preparative straight phase HPLC. It was shown that the potency resides in the (+)-enantiomer (pEC50 7.11). The synthesized compounds seem to be selective for the UII receptor as no activities were observed at the closely related SSTR3 and 5 receptors.
