54166-67-5

Basic information

• Product Name: Acetic acid, [(2-cyano-3-methoxyphenyl)amino]oxo-, ethyl ester
• CAS NO: 54166-67-5
• Molecular Formula: C12H12N2O4
• Molecular Weight: 248.238
• Mol File: 54166-67-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Acetic acid, [(2-cyano-3-methoxyphenyl)amino]oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [(2-cyano-3-methoxyphenyl)amino]oxo-, ethyl ester(54166-67-5)
• EPA Substance Registry System: Acetic acid, [(2-cyano-3-methoxyphenyl)amino]oxo-, ethyl ester(54166-67-5)

Safety Data

• Hazardous Substances Data: 54166-67-5(Hazardous Substances Data)

Upstream product

• 1591-37-3 2-amino-6-methoxybenzonitrile 
• 4755-77-5 Ethyl oxalyl chloride 
• 38469-85-1 2-methoxy-6-nitrobenzonitrile 

Relevant articles and documents

N-(Aminophenyl)oxamic Acids and Esters as Potent, Orally Active Antiallergy Agents

A series of N-(2-cyano-substituted-phenyl)oxamates was prepared by acylation of the appropriate anthranilonitrile with ethyloxalyl chloride.Hydrolysis with sodium hydroxide gave the corresponding oxamic acid sodium salts.These compounds were extremely potent when tested in the rat passive cutaneous anaphylaxis (PCA assay either by the ip or the po route of administration).One of the sodium salts, oxoacetic acid sodium salt (11a, Wy-41 195), has ED50 value of 0.07 mg/kg po and has been selected for further evaluation.

Pyridyl oxamic acid derivatives and use in the prevention of allergic reactions

Anti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: STR1 in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, α-naphthyl, βnaphthyl, phenyl, 2,6-dichlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy(lower)-alkoxy, 2-(lower alkoxy oxalyloxy) ethoxy, benzyloxy, N-mono-and di-lower alkylamino(lower)-alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono-and di-lower alkylamino, phenylazo, carboxy, lower alkylcarbonyl, cyano, carb(lower)alkoxy, phenoxy(lower)alkoxy, lower alkoxyoxalamido and lower alkoxyoxalamidophenoxy radicals; B, when taken alone, is a member selected from the group consisting of --OH, lower alkoxy, --NH2, --NHOH, cyclohexyloxy and phenoxy; and Y is a member selected from the group consisting of oxygen and when taken with B and the carbon atom to which they are attached, forms the moiety STR2

Oxanilic acids, a new series of orally active antiallergic agents

A large number of oxanilic acid esters and N heteroaryl oxamic acid esters were prepared and found to have antiallergic activity using the rat passive cutaneous anaphylaxis (PCA) test. Many of the oxanilic acid esters are active orally, with the most active species having an aryl 2' carbamoyl group and a 3' methoxy group. Hydrolysis of the ester from the oxanilic ester moiety causes a loss of oral activity.