54224-25-8Relevant articles and documents
Directing Neuronal Signaling through Cell-Surface Glycan Engineering
Pulsipher, Abigail,Griffin, Matthew E.,Stone, Shannon E.,Brown, Joshua M.,Hsieh-Wilson, Linda C.
, p. 6794 - 6797 (2014)
The ability to tailor plasma membranes with specific glycans may enable the control of signaling events that are critical for proper development and function. We report a method to modify cell surfaces with specific sulfated chondroitin sulfate (CS) glycosaminoglycans using chemically modified liposomes. Neurons engineered to display CS-E-enriched polysaccharides exhibited increased activation of neurotrophin-mediated signaling pathways and enhanced axonal growth. This approach provides a facile, general route to tailor cell membranes with biologically active glycans and demonstrates the potential to direct important cellular events through cell-surface glycan engineering.
OXAMAZIN ANTIBIOTICS
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Paragraph 0191; 0192, (2014/09/29)
Disclosed herein are oxamazin monobactam compounds and their use as antibiotics resistant to degradation by β-lactamases. Also disclosed are pharmaceutical compositions containing the compounds and methods of synthesis.
CROSSLINKING REAGENTS, METHODS, AND COMPOSITIONS FOR STUDYING PROTEIN-PROTEIN INTERACTIONS
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Page/Page column 15, (2013/02/27)
The invention provides reagents, methods, and compositions for studying protein-protein interactions. The inventive system and methods allow the analysis of protein-protein interactions in vivo and in vitro. Advantages offered by various embodiments of th