861445-47-8

Basic information

• Product Name: (S)-2-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-acetylamino]-3-phenyl-propionamide
• CAS NO: 861445-47-8
• Molecular Weight: 367.361
• Mol File: 861445-47-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-acetylamino]-3-phenyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-acetylamino]-3-phenyl-propionamide(861445-47-8)
• EPA Substance Registry System: (S)-2-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-acetylamino]-3-phenyl-propionamide(861445-47-8)

Safety Data

• Hazardous Substances Data: 861445-47-8(Hazardous Substances Data)

Upstream product

• 54224-25-8 t-butyl (1,3-dioxo-1,3-dihydroisoindol-2-yloxy)acetate 
• 65864-22-4 (S)-2-amino-3-phenylpropionamide hydrochloride 
• 134724-87-1 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]acetic acid 

Downstream Products

• 861445-51-4 [(S)-2-{(S)-2-[((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-methoxycarbamoyl]-pyrrolidin-1-yl}-1-(4-hydroxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by α-aminoxy acids

Endomorphin-2 (H-Tyr-Pro-Phe-Phe-NH2, EM-2) is a putative endogenous μ-opioid receptor ligand. To study the structure-activity relationship against its receptor, we introduced N-O turns into EM-2 and got the analogues with potent affinities for μ-opioid receptor. Our results indicated that N-O turn structures at the Pro2-aminoxy-Phe 3 position of EM-2 analogues played important roles for their affinities. These novel analogues with N-O turns provided a new approach to develop potent analgesics related to EM-2.