5429-01-6

Basic information

• Product Name: 4-methylquinolin-6-ol
• CAS NO: 5429-01-6
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.1846
• Mol File: 5429-01-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 330°C at 760 mmHg
• Flash Point: 153.4°C
• Density: 1.21g/cm³
• Vapor Pressure: 8.93E-05mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 4-methylquinolin-6-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylquinolin-6-ol(5429-01-6)
• EPA Substance Registry System: 4-methylquinolin-6-ol(5429-01-6)

Safety Data

• Hazardous Substances Data: 5429-01-6(Hazardous Substances Data)

Usage

General Description

4-methylquinolin-6-ol, also known as 4-methyl-6-hydroxyquinoline, is a chemical compound with the molecular formula C10H9NO. It is a quinoline derivative with a methyl group at the 4-position and a hydroxyl group at the 6-position. 4-methylquinolin-6-ol is a pale yellow solid with a strong fluorescent property and is widely used in organic synthesis and as a fluorescent probe in biological applications. 4-methylquinolin-6-ol is also known for its antimicrobial and antifungal properties, and it is commonly used in the production of pharmaceuticals, dyes, and plastic additives. It has potential applications in the development of new drugs and is a valuable tool in chemical and biological research.

Upstream product

• 41037-26-7 6-methoxy-4-methylquinoline 
• 123-30-8 4-amino-phenol 
• 78-94-4 methyl vinyl ketone 

Relevant articles and documents

Expansion of the aromatic part of Cinchona alkaloids. Annulation of quinolines with phenoxazine motifs

An oxidative cross-coupling strategy for quinoline ring annulation in Cinchona alkaloids has been developed. Key-reaction optimization by changing oxidants and adjusting the nucleophilicity of the 2-aminophenols led to cupreine and cupreidine expanded with the phenoxazinone unit in 56–75% yield. The stereochemical integrity of the obtained alkaloid structures was confirmed by combined experimental and computed CD and NMR data. The conformational study revealed a fast equilibrium of the three conformers, differing in the orientation of the pyrido[a-3,2]phenoxazine moiety.

Process for the synthesis of quinoline derivatives

The present invention provides an improved process for the synthesis of quinoline derivatives. More particularly the present invention provides an improved and economical process for the synthesis of quinoline derivatives by the reaction of aniline/substituted anilines using two different catalysts, ferric chloride and zinc chloride in a one-pot set up reaction.