54469-44-2

Basic information

• Product Name: 1-Piperazineethanol,-alpha--(methoxymethyl)-(9CI)
• Synonyms: 1-Piperazineethanol,-alpha--(methoxymethyl)-(9CI)
• CAS NO: 54469-44-2
• Molecular Formula: C8H18N2O2
• Molecular Weight: 174.24072
• Product Categories: PIPERIDINE
• Mol File: 54469-44-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 287.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.034±0.06 g/cm3(Predicted)
• PKA: 14.21±0.20(Predicted)
• CAS DataBase Reference: 1-Piperazineethanol,-alpha--(methoxymethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazineethanol,-alpha--(methoxymethyl)-(9CI)(54469-44-2)
• EPA Substance Registry System: 1-Piperazineethanol,-alpha--(methoxymethyl)-(9CI)(54469-44-2)

Safety Data

• Hazardous Substances Data: 54469-44-2(Hazardous Substances Data)

Usage

Molecular weight

161.24 g/mol

Derivative of piperazine

Used as an anthelmintic in veterinary medicine

Substitution

Alpha-(methoxymethyl) refers to a methoxy group attached to the carbon position adjacent to the hydroxyl group of piperazineethanol

Potential pharmacological activity

Due to structural similarity to other piperazine derivatives

Further research needed

To determine specific biological effects and potential applications

Limited information available

About its properties and uses

Caution advised

When handling this chemical

Upstream product

• 930-37-0 glycidyl methyl ether 
• 110-85-0 piperazine 

Relevant articles and documents

KINETICS OF THE REACTION OF PIPERAZINE WITH 1-METHOXY-2,3-EPOXYPROPANE

The quantitative relationships governing the formation of N-alkyl and N,N'-dialkylpiperazines were studied.An increase in the yield of the N-alkylpiperazines can be achieved by increasing the temperature and reducing the concentration of the α-oxide in the reaction mass.Comparison of the two investigated reactions indicates that a push-pull mechanism involving two molecules of the reagents and a solvent molecule is realized.

SYNTHESIS OF MONO- AND BIS(HYDROXYALKYL)PIPERAZINES.

The known methods for production of mono- and bis(hydroxyalkyl)piperazines are based on the reaction of ethylene oxide with unsubstituted piperazine, but the connection between alkylation of piperazine and the side reaction of oligomerization of alpha -oxides under the influence of catalytic amounts of piperazine has still not been clarified. The interaction of piperazine with substituted alpha -oxides has not been studied at all. We showed with reference to the reactions of piperazine with substituted alpha -oxides that opening of the oxirane ring proceeds exclusively with formation of mono- (I-IV) and N,N prime -bis(hydroxyalkyl)piperazines (V-VIII) in yields of 85-95% calculated on the alpha -oxide. The authors show that the two molecules of the asymmetric alpha -oxide add on exclusively at the nitrogen atoms of the heterocycle, and that oligomerization of the alpha -oxide and addition of its second molecule at the hydroxyl groups of mono(hydroxyalkyl)piperazines (I-IV) make no appreciable contribution. The presence of free hydroxyl groups in compounds (I-VIII) offers possibilities of chemical bonding in epoxy compositions.