930-37-0

Basic information

• Product Name: GLYCIDYL METHYL ETHER
• Synonyms: GLYCIDYL METHYL ETHER;1,2-EPOXY-3-METHOXYPROPANE;(methoxymethyl)-oxiran;(Methoxymethyl)oxirane;(methoxymethyl)-Oxirane;1,2-epoxy-3-methoxy-propan;2-(Methoxymethyl)oxirane;3-Methoxy-1,2-epoxypropane
• CAS NO: 930-37-0
• Molecular Formula: C₄H₈O₂
• Molecular Weight: 88.11
• EINECS: 213-216-7
• Product Categories: Oxiranes;Simple 3-Membered Ring Compounds
• Mol File: 930-37-0.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 110°C
• Flash Point: 24°C
• Appearance: /
• Density: 0,98 g/cm3
• Refractive Index: 1.4080-1.4140
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Toluene (Slightly)
• CAS DataBase Reference: GLYCIDYL METHYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: GLYCIDYL METHYL ETHER(930-37-0)
• EPA Substance Registry System: GLYCIDYL METHYL ETHER(930-37-0)

Safety Data

• Statements: 10
• Safety Statements: 16
• RIDADR: 3271
• RTECS: TZ3530000
• HazardClass: 3.1
• PackingGroup: II
• Hazardous Substances Data: 930-37-0(Hazardous Substances Data)

Usage

Uses

2-(Methoxymethyl)oxirane is used in the fixation of biological tissues or in collagen bioprosthetic fixation processes.

General Description

Clear colorless liquid.

Air & Water Reactions

Highly flammable. May be sensitive to exposure to air(peroxide formation). . Water soluble.

Reactivity Profile

GLYCIDYL METHYL ETHER, an ether can act as a base. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.

Fire Hazard

GLYCIDYL METHYL ETHER is flammable.

InChI:InChI=1/C4H8O2/c1-5-2-4-3-6-4/h4H,2-3H2,1H3

Upstream product

• 26438-92-6 2-chloro-3-methoxy-propan-1-ol 
• 4151-97-7 1-chloro-3-methoxypropan-2-ol 
• 627-40-7 methylallylether 
• 67-56-1 methanol 
• 106-89-8 epichlorohydrin 
• 124-41-4 sodium methylate 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 186581-53-3 diazomethane 
• 107-31-3 Methyl formate 
• 106-92-3 Allyl glycidyl ether 
• 33100-27-5 15-crown-5 
• 74-88-4 methyl iodide 
• 227945-00-8 diethyl 2-amino-6-[(hydroxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate sodium 
• 142-28-9 1,3-Dichloropropane 

Downstream Products

• 53146-34-2 1-isopropoxy-3-methoxy-2-propanol 
• 93372-65-7 2-hydroxy-3-methoxypropylamine 
• 26072-85-5 β-Hydroxyethyl-(β-hydroxy-γ-methoxypropyl)-amin 
• 32017-84-8 1-methoxy-3-phenoxy-propan-2-ol 
• 54469-44-2 N-(2-hydroxy-3-methoxypropyl)piperazine 
• 92037-01-9 N,N'-bis(2-hydroxy-3-methoxypropyl)piperazine 
• 40492-31-7 4-methoxymethyl-1,3-dioxolan-2-one 
• 187737-37-7 propene 
• 115-10-6 Dimethyl ether 
• 62498-14-0 trans-1,3-bis(perfluoro-tert-butyl)propene 
• 39504-13-7 3-hydroxy-3-(phenylthio)propyl methyl ether 
• 123295-65-8 2-acetoxy-3-(phenylthio)propyl methyl ether 
• 123295-64-7 2-benzoyloxy-3-(phenylthio)propyl methyl ether 
• 121485-55-0 Butyl-[4-methoxymethyl-3-phenyl-oxazolidin-(2Z)-ylidene]-amine 

Relevant articles and documents

Rational design 2-hydroxypropylphosphonium salts as cancer cell mitochondria-targeted vectors: Synthesis, structure, and biological properties

It has been shown for a wide range of epoxy compounds that their interaction with triphenylphosphonium triflate occurs with a high chemoselectivity and leads to the formation of (2-hydroxypropyl)triphenylphosphonium triflates 3 substituted in the 3-position with an alkoxy, alkylcarboxyl group, or halogen, which were isolated in a high yield. Using the methodology for the disclosure of epichlorohydrin with alcohols in the presence of boron trifluoride ether-ate, followed by the substitution of iodine for chlorine and treatment with triphenylphosphine, 2-hydroxypropyltriphenylphosphonium iodides 4 were also obtained. The molecular and supramolec-ular structure of the obtained phosphonium salts was established, and their high antitumor activity was revealed in relation to duodenal adenocarcinoma. The formation of liposomal systems based on phosphonium salt 3 and L-α-phosphatidylcholine (PC) was employed for improving the bioavailabil-ity and reducing the toxicity. They were produced by the thin film rehydration method and exhibited cytotoxic properties. This rational design of phosphonium salts 3 and 4 has promising potential of new vectors for targeted delivery into mitochondria of tumor cells.

Role of Organic Fluoride Salts in Stabilizing Niobium Oxo-Clusters Catalyzing Epoxidation

We present here that easily available organic salts can stabilize/modify niobium (Nb) oxo-clusters. The as-synthesized Nb oxo-clusters have been characterized by various methods. These Nb oxo-clusters were catalytically active for the epoxidation of allylic alcohols and olefins with H2O2 as an oxidant. Notably, Nb-OC@TBAF-0.5 appeared as highly dispersed nanosized particles and showed the highest catalytic activity, which can be attributed to the following reasons on the basis of characterization. First, the strong coordination of fluorine ions with Nb sites and the steric protection with bulky organic cations led to high stabilization and dispersion of the oxo-clusters in the course of the reaction. Second, a hydrogen-bond interaction between the coordinated fluorine atom and the -OH group of allylic alcohol favored the epoxidation reaction. Third, the electron density of Nb sites decreased due to the strong electron-withdrawing ability of F- adjacent to Nb sites, thus promoting the electrophilic oxygen transfer to the CC bond.

Preparation method of nifuratel related substance A hydrochloride

The invention provides a preparation method of nifuratel related substance A hydrochloride. The preparation method comprises the following steps: (1) reacting sodium methoxide with epichlorohydrin to prepare 2-(methoxymethyl)-oxetane; (2) dropwise adding the 2-(methoxymethyl)-oxygen heterocyclic propane into hydrazine hydrate, so as to prepare 3-methoxy-2-hydroxyl-propyl hydrazine; (3) adding diethyl carbonate into the 3-methoxy-2-hydroxy-propyl hydrazine, and preparing a nifuratel related substance A, namely, N-amino-5-methoxymethyl-2-oxazolidinone; and (4) salifying the prepared N-amino-5-methoxymethyl-2-oxazolidinone and concentrated hydrochloric acid, so as to prepare the hydrochloride of the nifuratel related substance A. According to the preparation method of the nifuratel related substance A hydrochloride, the nifuratel related substance A hydrochloride can be conveniently and rapidly obtained, and the obtained nifuratel related substance A hydrochloride is high in yield and good in purity.