5448-36-2

Basic information

• Product Name: 3-methyl-N,N-dipropan-2-yl-benzamide
• Synonyms: 3-methyl-N,N-dipropan-2-yl-benzamide;3-Methyl-N,N-bis(1-methylethyl)benzamide;N,N-Diisopropyl-3-methylbenzamide
• CAS NO: 5448-36-2
• Molecular Formula: C₁₄H₂₁NO
• Molecular Weight: 219.32
• Mol File: 5448-36-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 338.1°Cat760mmHg
• Flash Point: 146.2°C
• Appearance: /
• Density: 0.962g/cm³
• Vapor Pressure: 0.0001mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: 3-methyl-N,N-dipropan-2-yl-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-N,N-dipropan-2-yl-benzamide(5448-36-2)
• EPA Substance Registry System: 3-methyl-N,N-dipropan-2-yl-benzamide(5448-36-2)

Safety Data

• Hazardous Substances Data: 5448-36-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H21NO/c1-10(2)15(11(3)4)14(16)13-8-6-7-12(5)9-13/h6-11H,1-5H3

Upstream product

• 4294-57-9 para-methylphenylmagnesium bromide 
• 155496-73-4 2-(tert-butylsulfonyl)-N,N-diisopropyl-5-methylbenzamide 
• 20383-28-2 N,N-diisopropyl benzamide 
• 161431-82-9 2-tert-Butylsulfanyl-N,N-diisopropyl-benzamide 
• 155496-72-3 2-(tert-butylsulfonyl)-N,N-diisopropylbenzamide 
• 108-18-9 diisopropylamine 
• 1711-06-4 3-Methylbenzoyl chloride 
• 99-04-7 m-Toluic acid 

Downstream Products

• 1351765-32-6 (E)-5-methyl-2-(prop-1-enyl)benzoic acid 
• 1351765-14-4 3-methyl-N,N-diisopropyl-2-formylbenzamide 
• 1351765-11-1 5-methyl-N,N-diisopropyl-2-formylbenzamide 
• 72288-75-6 3-hydroxy-4-methylisobenzofuran-1(3H)-one 
• 177166-16-4 3-hydroxy-6-methylisobenzofuran-1(3H)-one 
• 1375931-09-1 2-bromo-N,N-diisopropyl-5-methylbenzamide 
• 1392473-20-9 2-hydroxy-N,N-diisopropyl-5-methylbenzamide 
• 1557179-00-6 2-cyano-N,N-diisopropyl-5-methylbenzamide 
• 1527480-00-7 (2-iodo-3,5-dimethylphenyl)(piperidin-1-yl)methanone 
• 34665-58-2 6-methyl-2,3-diphenyl-1H-inden-1-one 
• 20359-57-3 1-(3-methylphenyl)pentan-1-one 

Relevant articles and documents

Z-Selective Fluoroalkenylation of (Hetero)Aromatic Systems by Iodonium Reagents in Palladium-Catalyzed Directed C?H Activation

The direct and catalytic incorporation of fluorine containing molecular motifs into organic compounds resulting high-value added chemicals represents a rapidly evolving part of synthetic methodologies, thus this area is in the focus of pharmaceutical and agrochemical research. Herein we report a stereoselective procedure for direct fluorovinylation of aromatic and heteroaromatic scaffolds. This methodology development has been realized by palladium-catalyzed ortho C?H activation reaction of aniline derivatives featuring the regioselectivity via directing groups such as secondary of tertiary amides, ureas or ketones. The application of non-symmetrical aryl(fluoroalkenyl)-iodonium salts as fluoroalkenylating agents allowed mild reaction conditions in general for this transformation. The scope and limitations have been thoroughly investigated and the feasibility has been demonstrated by more than 50 examples.

An efficient method for the preparation of styrene derivatives via Rh(III)-catalyzed direct C-H vinylation

The development of a method for the Rh(III)-catalyzed direct vinylation of an aromatic C-H bond to give functionalized styrenes in good yield, using vinyl acetate as a convenient and inexpensive vinyl source, is reported. High functional group tolerance is demonstrated for electronically distinct arenes as well as different directing groups. Mechanistic investigation resulted in the characterization of a novel rhodium-metallacycle, which represents the first X-ray structure of a [1,2]-Rh(III)-alkenyl addition adduct.

Ruthenium-catalyzed ortho-C-H halogenations of benzamides

[Ru3(CO)12] and AgO2C(1-Ad) enabled the first ruthenium-catalyzed intermolecular halogenations of arenes via C-H activation. Thereby, brominations and iodinations of electron-rich and electron-deficient benzamides were ach