5454-05-7

Basic information

• Product Name: 2-(5-phenyl-1H-tetrazol-1-yl)pyridine
• Synonyms: 2-(5-Phenyl-tetrazol-1-yl)-pyridine
• CAS NO: 5454-05-7
• Molecular Formula: C₁₂H₉N₅
• Molecular Weight: 223.2334
• Mol File: 5454-05-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 435.3°C at 760 mmHg
• Flash Point: 217.1°C
• Density: 1.31g/cm³
• Vapor Pressure: 8.84E-08mmHg at 25°C
• Refractive Index: 1.709
• CAS DataBase Reference: 2-(5-phenyl-1H-tetrazol-1-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-phenyl-1H-tetrazol-1-yl)pyridine(5454-05-7)
• EPA Substance Registry System: 2-(5-phenyl-1H-tetrazol-1-yl)pyridine(5454-05-7)

Safety Data

• Hazardous Substances Data: 5454-05-7(Hazardous Substances Data)

Usage

General Description

2-(5-phenyl-1H-tetrazol-1-yl)pyridine is a chemical compound with the molecular formula C13H9N5. It is a heterocyclic organic compound that contains a phenyl group and a pyridine ring linked by a tetrazole ring. 2-(5-phenyl-1H-tetrazol-1-yl)pyridine is used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules, including potential drug candidates. It also exhibits potential biological activities, such as antibacterial and antifungal properties, making it a promising candidate for further research and development in the field of medicinal chemistry. Additionally, its unique structure and reactivity make it a valuable tool for the study of chemical reactions and mechanisms in organic synthesis.

Upstream product

• 4589-12-2 N-(pyrid-2-yl)benzamide 
• 78455-28-4 N-(2'-pyridyl)benzimidoyl chloride 
• 504-29-0 2-aminopyridine 
• 7504-87-2 N,N'-dibenzoylimido-1,2-dihydropyridine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 779-24-8 2-phenyl[1,2,4]triazolo[1,5-a]pyridine 

Relevant articles and documents

Preparation of 1,5-disubstituted tetrazoles under phase-transfer conditions

Imidoyl chlorides, obtained by common methods from a wide range of aromatic mono- and diamides, are smoothly converted to the corresponding tetrazoles in high yields by treatment with NaN3 under phase-transfer conditions.

Nucleophilic Displacement of Primary Amino Groups via 1-Substituted 4-Tosylimidazoles

Two methods are discribed for the replacement of primary amino groups, situated either α or γ to a heterocyclic nitrogen atom, by ethoxy, alkylthio, and arylthio substituents, by Wittig reagents, and by hydrogen.Both methods involve transformation of the primary amino group into a nucleofugic pendant heterocycle.The first converts the primary amino group into a 5-phenyl-1-tetrazolyl substituent by benzoylation, formation of the imidoyl chloride, and reaction with sodium azide, while the second converts the primary amino group into a 1-(4-tosylimidazolyl) substituent by reaction with triethyl orthoformate and acid to give the (ethoxymethylene)amino derivative, which is then condensed with tosylmethyl isocyanide (TosMIC) anion.The 1-(4-tosylimidazolyl) substituent is shown to be more susceptible to nucleophilic displacement by a wider range of nucleophiles.