5470-14-4

Basic information

• Product Name: (6-BroMo-benzo[1,3]dioxol-5-yl)-aceticacid
• Synonyms: (6-BroMo-benzo[1,3]dioxol-5-yl)-aceticacid;2-(6-bromo-1,3-benzodioxol-5-yl)acetic acid
• CAS NO: 5470-14-4
• Molecular Formula: C₉H₇BrO₄
• Molecular Weight: 259.05348
• Mol File: 5470-14-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 390°C at 760 mmHg
• Flash Point: 189.7°C
• Appearance: /
• Density: 1.795g/cm³
• Vapor Pressure: 8.79E-07mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: (6-BroMo-benzo[1,3]dioxol-5-yl)-aceticacid(CAS DataBase Reference)
• NIST Chemistry Reference: (6-BroMo-benzo[1,3]dioxol-5-yl)-aceticacid(5470-14-4)
• EPA Substance Registry System: (6-BroMo-benzo[1,3]dioxol-5-yl)-aceticacid(5470-14-4)

Safety Data

• Hazardous Substances Data: 5470-14-4(Hazardous Substances Data)

Usage

General Description

(6-Bromo-benzo[1,3]dioxol-5-yl)-acetic acid is a chemical compound with the formula C9H7BrO4. It is a derivative of benzo[1,3]dioxole, which is a widely used structural motif in organic chemistry. (6-BroMo-benzo[1,3]dioxol-5-yl)-aceticacid contains a bromine atom and an acetic acid group attached to the benzo[1,3]dioxole ring. The presence of the bromine atom makes it useful as a synthetic intermediate for the preparation of various organic compounds. It can also be used in medicinal chemistry research for the development of potential pharmaceuticals. Additionally, the acetic acid group gives it some acidic properties, making it useful in certain chemical reactions and synthetic processes.

InChI:InChI=1/C9H7BrO4/c10-6-3-8-7(13-4-14-8)1-5(6)2-9(11)12/h1,3H,2,4H2,(H,11,12)

Upstream product

• 5434-50-4 2-(5-bromobenzo[d][1,3]dioxol-6-yl)acetonitrile 
• 956084-13-2 (6-bromo-benzo[1,3]dioxol-5-yl)-pyruvic acid 
• 2861-28-1 1,3-benzodioxole-5-acetic acid 
• 6642-34-8 6-bromopiperonyl alcohol 
• 64603-67-4 5-bromo-6-(chloromethyl)benzo[d][1,3]dioxole 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 889115-21-3 2-{5-bromobenzo[d][1,3]dioxol-6-yl}acetaldehyde 
• 5025-53-6 5-bromo-6-methylbenzo[d][1,3]dioxole 
• 5434-47-9 5-bromo-6-bromomethylbenzo[1,3]dioxole 

Downstream Products

• 130862-09-8 2-(6-bromo-benzo[1,3]dioxol-5-yl)-3t-(2-methoxy-6-nitro-phenyl)-acrylic acid 
• 131410-39-4 2-(6-bromo-benzo[1,3]dioxol-5-yl)-3t-(2-nitro-phenyl)-acrylic acid 
• 51665-84-0 methyl (6-bromobenzo<1,3>dioxol-5-yl)acetate 
• 58446-66-5 2-(5-bromobenzo[1,3]dioxol-6-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 
• 25888-41-9 1-(2-bromo-4,5-dimethoxybenzyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline 
• 496817-68-6 N-(1-phenylethyl)-2-(2-bromo-4,5-methylenedioxyphenyl)acetamide 
• 496817-70-0 N-[2-(2-bromo-4,5-methylenedioxyphenyl)ethhyl]-N-(1-phenylethyl)-2-(2-bromo-4,5-dimethoxyphenyl)acetamide 
• 5434-50-4 2-(5-bromobenzo[d][1,3]dioxol-6-yl)acetonitrile 
• 132569-41-6 3t-(2-amino-phenyl)-2-(6-bromo-benzo[1,3]dioxol-5-yl)-acrylic acid 
• 111089-64-6 3t-(2-amino-6-methoxy-phenyl)-2-(6-bromo-benzo[1,3]dioxol-5-yl)-acrylic acid 
• 7687-04-9 N-(4-benzyloxy-3-methoxy-phenethyl)-2-(6-bromo-benzo[1,3]dioxol-5-yl)-acetamide 
• 1173352-64-1 2-(2-bromo-4,5-methylenedioxyphenyl)-N-(4-benzyloxy-2,3-dimethoxyphenethyl)acetamide 
• 1293324-43-2 (benzo[1,3]dioxol-5-ylmethyl)(cyclohex-2-enyl)carbamic acid tert-butyl ester 
• 60229-58-5 6-(benzyloxy)-1-((6-bromobenzo[d][1,3]dioxol-5-yl)methyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Enantioselective Syntheses of Strychnos and Chelidonium Alkaloids through Regio- and Stereocontrolled Cooperative Catalysis

We describe enantioselective syntheses of strychnos and chelidonium alkaloids. In the first case, indole acetic acid esters were established as excellent partner nucleophiles for enantioselective cooperative isothiourea/Pd catalyzed α-alkylation. This provides products containing indole-bearing stereocenters in high yield and with excellent levels of enantioinduction in a manner that is notably independent of the N-substituent. This led to concise syntheses of (?)-akuammicine and (?)-strychnine. In the second case, the poor performance of ortho-substituted cinnamyl electrophiles in the enantioselective cooperative isothiourea/Ir catalyzed α-alkylation was overcome by appropriate substituent choice, leading to enantioselective syntheses of (+)-chelidonine, (+)-norchelidonine, and (+)-chelamine.

Oxidation nandina philippine alkali synthetic method and its application

The invention discloses a synthetic method of oxidized nantenine and application of the oxidized nantenine. The synthetic method of the oxidized nantenine comprises the following steps: taking 2-(benzo[d][1,3]dioxol-5-yl)acetic acid and 3,4-dimethoxy phenethylamine as starting materials, and conducting seven-step reaction to synthesize the oxidized nantenine. Compared with the prior art, the organic complete synthetic method of the oxidized nantenine is provided by the invention; experiments indicate that the oxidized nantenine has a proliferation inhibitory activity against a plurality of human tumor cell strains, shows up a good antitumor activity in vitro, is excellent in potential medicinal value, and can be applied to preparation of various anti-tumor drugs.

Rapid synthesis and zebrafish evaluation of a phenanthridine-based small molecule library

A Heck cyclisation approach is described for the rapid synthesis of a library of natural product-like small molecules, based on the phenanthridine core. The synthesis of a range of substituted benzylamine building blocks and their incorporation into the library is reported, together with a highly selective cis-dihydroxylation protocol that enables access to the target compounds in an efficient manner. Biological evaluation of the library using zebrafish phenotyping has led to the discovery of compound 20c, a novel inhibitor of early-stage zebrafish embryo development.