64603-67-4

Basic information

• Product Name: 5-BROMO-6-(CHLOROMETHYL)-1,3-BENZODIOXOLE
• Synonyms: 5-broMo-6-(chloroMethyl)-2H-1,3-benzodioxole;5-BroMo-6-(chloroMethyl)benzo[d][1,3]dioxole
• CAS NO: 64603-67-4
• Molecular Formula: C₈H₆BrClO₂
• Molecular Weight: 249.49
• Mol File: 64603-67-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 311.6°C at 760 mmHg
• Flash Point: 142.3°C
• Appearance: /
• Density: 1.726g/cm³
• Vapor Pressure: 0.00102mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 5-BROMO-6-(CHLOROMETHYL)-1,3-BENZODIOXOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-6-(CHLOROMETHYL)-1,3-BENZODIOXOLE(64603-67-4)
• EPA Substance Registry System: 5-BROMO-6-(CHLOROMETHYL)-1,3-BENZODIOXOLE(64603-67-4)

Safety Data

• Hazardous Substances Data: 64603-67-4(Hazardous Substances Data)

Usage

General Description

5-Bromo-6-(chloromethyl)-1,3-benzodioxole is a chemical compound with the molecular formula C8H6BrClO2. It belongs to the class of benzodioxole compounds and is a halogenated derivative of 1,3-benzodioxole. This chemical is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a building block in the production of various chemicals and serves as an intermediate in organic synthesis. 5-Bromo-6-(chloromethyl)-1,3-benzodioxole has potential application in drug discovery and development due to its structural features. However, it is important to handle this chemical with care due to its potential health hazards and environmental impact.

InChI:InChI=1/C8H6BrClO2/c9-6-2-8-7(11-4-12-8)1-5(6)3-10/h1-2H,3-4H2

Upstream product

• 6642-34-8 6-bromopiperonyl alcohol 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 274-09-9 Methylenedioxybenzene 
• 20850-43-5 5-(chloromethyl)-1,3-benzodioxole 
• 495-76-1 piperonol 

Downstream Products

• 5434-50-4 2-(5-bromobenzo[d][1,3]dioxol-6-yl)acetonitrile 
• 112378-10-6 8-benzyloxy-N-benzoyl-1-(2'-bromo-4',5'-methylenedioxybenzyl)-1,2-dihydro-7-methoxyisoquinoline-1-carbonitrile 
• 86817-56-3 8-benzyloxy-1-(2'-bromo-4',5'-methylenedioxybenzyl)-7-methoxyisoquinoline 
• 130-86-9 protopine 
• 52886-06-3 hippadine 
• 40360-71-2 anhydrolycorine-7-one 
• 94670-91-4 1-phenyl-2-(2'-bromo-4',5'-methylenedioxyphenyl)ethanone 
• 112378-13-9 8-benzyloxy-1-(2'-bromo-4',5'-methylenedioxybenzyl)-7-methoxy-N-methylisoquinolinium iodide 
• 112378-15-1 8-benzyloxy-1-(2'-bromo-4',5'-methylenedioxybenzyl)-1,2,3,4-tetrahydro-7-methoxy-N-methylisoquinoline 
• 5470-14-4 (6-bromobenzo[1,3]dioxol-5-yl)acetic acid 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 

Relevant articles and documents

2-Amino-purine derivative compound, preparing method and use thereof

According to one aspect, provided are a purine compound, a stereoisomer, a derivative, a solvate, or a pharmaceutically acceptable salt thereof, a manufacturing method thereof and uses thereof. According to the same, the compound, and the stereoisomer, derivative, solvate, or pharmaceutically acceptable salt thereof have low cytotoxicity, and exhibit high selective inhibitory activity against HSP90, and antiproliferative effect of cancer cells, thereby being useful for preventing or treating cancer.(AA) Density(BB) Compound(CC) andbeta;- tubulinCOPYRIGHT KIPO 2018

Ethyl cinnamate derivatives as promising high-efficient acaricides against Psoroptes cuniculi: Synthesis, bioactivity and structure-activity relationship

This paper reported the synthesis, structure-activity relationship (SAR) and acaricidal activity in vitro against Psoroptes cuniculi, a mange mite, of 25 ethyl cinnamate derivatives. All target compounds were synthesized and elucidated by means of MS, 1H- and 13C-NMR analysis. The results showed that 24 out of 25 tested compounds at 1.0 mg/mL demonstrated acaricidal activity in varying degrees. Among them, 6, 15, 26, 27 and 30 showed significant activity with median lethal concentration values (LC50) of 89.3, 119.0, 39.2, 29.8 and 41.2 μg/mL, respectively, which were 2.1- to 8.3-fold the activity of ivermectin (LC50=247.4 μg/mL), a standard drug in the treatment of Psoroptes cuniculi. Compared with ivermectin, with a median lethal time value (LT50) of 8.9 h, 27 and 30 showed smaller LTM50 values of 7.9 and 1.3 h, respectively, whereas 6, 15 and 26 showed slightly larger LT50 values of 10.6, 11.0 and 10.4 h at 4.5 μmol/mL. SARs showed that the presence of o-NO2 or m-NO2 on the benzene ring significantly improved the activity, whereas the introduction of a hydroxy, methoxy, acetoxy, methylenedioxy, bromo or chloro group reduced the activity. (E)-Cinnamates were more effective than their (Z)-isomer. Nevertheless, the carbon-carbon double bond in the acrylic ester moiety was proven not to be essential to improve the activity of cinnamic acid esters. Thus, the results strongly indicate that cinnamate derivatives, especially their dihydro derivatives, should be promising candidates or lead compounds for the development of novel acaricides for the effective control of animal or human acariasis.