54895-19-1

Basic information

• Product Name: Dithiocarbamic acid benzyl ester
• Synonyms: Dithiocarbamic acid benzyl ester
• CAS NO: 54895-19-1
• Molecular Formula: C₈H₉NS₂
• Molecular Weight: 183.29
• Mol File: 54895-19-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 315.3°C at 760 mmHg
• Flash Point: 144.5°C
• Appearance: /
• Density: 1.265g/cm³
• Vapor Pressure: 0.000441mmHg at 25°C
• Refractive Index: 1.677
• CAS DataBase Reference: Dithiocarbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Dithiocarbamic acid benzyl ester(54895-19-1)
• EPA Substance Registry System: Dithiocarbamic acid benzyl ester(54895-19-1)

Safety Data

• Hazardous Substances Data: 54895-19-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H9NS2/c9-8(10)11-6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)

Upstream product

• 3012-37-1 benzyl thiocyanate 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 74237-98-2 trithioallophanic acid benzyl ester 
• 7664-41-7 ammonia 
• 507-09-5 tiolacetic acid 
• 513-74-6 ammonium dithiocarbamate 
• 620-05-3 iodomethylbenzene 
• 75-15-0 carbon disulfide 

Downstream Products

• 463-56-9 thiocyanic acid 
• 100-53-8 phenylmethanethiol 
• 5729-30-6 2-benzylsulfanyl-thiazole-4,5-dione 
• 30531-08-9 2-benzylthio-4,6-dioxo-5,6-dihydro-4H-1,3-thiazine 
• 60901-30-6 2-benzylsulfanyl-5,5-dimethyl-[1,3]thiazine-4,6-dione 
• 132791-51-6 2-benzylthio-6-methoxycarbonyl-4H-1,3-thiazin-4-one 
• 107938-65-8 [1-Dimethylamino-eth-(E)-ylidene]-dithiocarbamic acid benzyl ester 
• 87108-98-3 2-thiobenzyl-4-dimethylamino-4-ethoxycarbonyl-1-thia-3-aza-2-C₆H₅-butadiene 
• 88406-77-3 N,N-dimethyl N'-<(benzylthio) thiocarbonyl> formamidine 
• 103200-08-4 S-Benzyl-S-methyl iminodithiocarbonate hydroiodide 
• 209473-21-2 2-benzylsulfanyl-5-hydroxymethyl-4,5-dihydrothiazol-4-ol 
• 464180-55-0 2-benzylthio-4-hydroxy-4-methyl-5,6-dihydro-4H-1,3-thiazine 
• 464180-56-1 2-benzylsulfanyl-4-ethyl-5,6-dihydro-4H-[1,3]thiazin-4-ol 
• 139670-71-6 2-benzylthio-4-N,N-dimethylamino-1-thia-3-aza-1,3-butadiene 

Relevant articles and documents

ZrCl4/TMSCl as an efficient catalyst for synthesis of 4,6-substituted 2-alkylthio-6H-1,3-thiazines

4,6-Substituted-2-alkylthio-6H-1,3-thiazines were synthesized by the reaction of S-alkyl dithiocarbamates and α, β-unsaturated ketones in the presence of ZrCl4/TMSCl. The procedure is simple and efficient and gives good to high yields of produc

Synthesis, cytotoxic evaluation and molecular docking study of 2-alkylthio-4-(2,3,4-trimethoxyphenyl)-5-aryl-thiazoles as tubulin polymerization inhibitors

A series of cis-restricted 2-alkylthio-4-(2,3,4-trimethoxyphenyl)-5-aryl- thiazole analogues of combretastatin A-4 were synthesized and investigated for inhibition of cell proliferation against three cancer cell lines, HT-29, MCF-7, and AGS, and a normal mouse fibroblastic cell line, NIH-3T3, using an MTT assay. The biological study showed that 2-(methylthio) substituted compounds showed little cytotoxic activity against the four cell lines. In contrast, the presence of the 2-(benzylthio) group on the thiazole ring resulted in a significant improvement in cytotoxic activity relative to the 2-(methylthio) substituted derivatives. Furthermore, the inhibition of tubulin polymerization by some potent compounds was evaluated. All the compounds studied were moderate tubulin polymerization inhibitors. The flow cytometry analysis confirmed that the synthesized compounds led to cell cycle arrest at the G2/M phase. Docking simulation was performed to insert these compounds into the crystal structure of tubulin at the colchicine binding site to determine a probable binding model.

THIA-1 AZA-3 BUTADIENES SUBSTITUES: ACTION DU CETENE ET DERIVES

Novel, diversely substituted 1-thia 3-aza butadienes have been prepared and reacted with ketene or its derivatives.Via a general (4+2) cycloaddition reaction, they afford functionalised 6H-1,3-thiazine 6-ones, the electrophilic properties of which are described.This cycloaddition gives rise to other reaction products resulting from the addition of two or three molecules of ketene according to the nature of the substituents.