54923-63-6

Basic information

• Product Name: 5-chloro-3-phenylbenzofuran
• Synonyms: 5-chloro-3-phenylbenzofuran
• CAS NO: 54923-63-6
• Molecular Weight: 228.678
• Mol File: 54923-63-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 5-chloro-3-phenylbenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-phenylbenzofuran(54923-63-6)
• EPA Substance Registry System: 5-chloro-3-phenylbenzofuran(54923-63-6)

Safety Data

• Hazardous Substances Data: 54923-63-6(Hazardous Substances Data)

Upstream product

• 923595-09-9 5-chloro-2-(2-oxo-2-phenyl-ethoxy)-phenyl boronic acid 
• 71643-66-8 4-chloro-2-iodo phenol 
• 70-11-1 α-bromoacetophenone 
• 106-48-9 4-chloro-phenol 
• 62594-97-2 4-chloro-2-(1-phenylethenyl)phenol 
• 85-19-8 (5-chloro-2-hydroxyphenyl)phenylmethanone 
• 127-19-5 N,N-dimethyl acetamide 
• 100-42-5 styrene 
• 1193-00-6 sodium 4-chlorophenolate 
• 18859-48-8 2-(4-chlorophenoxy)-1-phenylethanone 

Relevant articles and documents

Nickel-Catalyzed Intramolecular Nucleophilic Addition of Aryl Halides to Aryl Ketones for the Synthesis of Benzofuran Derivatives

A nickel-catalyzed intramolecular nucleophilic addition reaction of aryl halides to aryl ketones for the formation of benzofuran derivatives has been developed. A number of substrates bearing electron-donating or electron-withdrawing groups were subjected to the standard reaction conditions, giving the corresponding products in moderate to good yields.

Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)participates in diverse cancer-associated signaling pathways, playing an oncogenic role in multiple human cancers, including hepatocellular carcinoma (HCC). Our recent works clarify that Pin1 modulates miRNAs biogenesis by interacting with ERK-phosphorylated exportin-5 (XPO5)and changing XPO5 conformation, giving a potential target for HCC treatment. Herein, we discover 4,6-bis(benzyloxy)-3-phenylbenzofuran (TAB29)as a novel Pin1 inhibitor that targets Pin1 PPIase domain. TAB29 potently inhibits Pin1 activity with the IC50 value of 874 nM and displays an excellent selectivity toward Pin1 in vitro. Cell-based biological evaluation reveals that TAB29 significantly suppresses cell proliferation of HCC cells through restoring the nucleus-to-cytoplasm export of XPO5 and upregulating mature miRNAs expression. Collectively, this work provides a promising small molecule lead compound for Pin1 inhibition, highlighting the therapeutic potential of miRNA-based treatment for human cancers.

TfOH-SiO2 as an efficient and recyclable catalyst for synthesis of 3-arylbenzofurans

A convenient process for the synthesis of 3-arylbenzofurans and their derivatives by 2-phenoxy-1-phenylethanones via TfOH-SiO2 catalyzed is developed. This method provides several advantages such as simple work-up procedure, simple post-treatme