54962-86-6

Basic information

• Product Name: 3,4-dichloro-N-(propan-2-yl)aniline
• Synonyms: 3,4-dichloro-N-(propan-2-yl)aniline
• CAS NO: 54962-86-6
• Molecular Formula: C₉H₁₁Cl₂N
• Molecular Weight: 204.09634
• Mol File: 54962-86-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 307.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.228±0.06 g/cm3(Predicted)
• PKA: 4.40±0.33(Predicted)
• CAS DataBase Reference: 3,4-dichloro-N-(propan-2-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dichloro-N-(propan-2-yl)aniline(54962-86-6)
• EPA Substance Registry System: 3,4-dichloro-N-(propan-2-yl)aniline(54962-86-6)

Safety Data

• Hazardous Substances Data: 54962-86-6(Hazardous Substances Data)

Upstream product

• 66172-16-5 4-azido-1,2-dichlorobenzene 
• 920-39-8 isopropylmagnesium bromide 
• 67-64-1 acetone 
• 95-76-1 m,p-dichloroaniline 

Downstream Products

• 1020670-13-6 (3,4-Dichloro-phenyl)-(1H-imidazol-2-ylmethyl)-isopropyl-amine 

Relevant articles and documents

Synthesis of 3-chloro-4-fluorophenyl-3,4-dichlorophenyl substituted thiocarbamide derivatives as potential antitubercular agents

A series of dihalosubstituted thiocarbamide derivatives (5a-e, 6a-e, 7a-e, and 8a-e) were synthesized as antitubercular agents. The structures of dihalosubstituted thiocarbamide derivatives were established on the basis of IR, 1H, 13C NMR, and mass spectral data. All the compounds were tested in vitro for antimycobacterial activity against Mycobacterium tuberculosis (ATCC-25177) by well-diffusion method and MIC by serial dilution method. Results of the antitubercular screening revealed that some of the compounds showed moderate to good antitubercular activity. Of all the compounds tested, two derivatives viz., 8d and 8e expressed MIC of 25 μg/ml, and one compound 7e showed MIC of 12.5 μg/ml against M. tuberculosis (ATCC-25177). Graphical Abstract: [Figure not available: see fulltext.]

A novel and efficient approach to mono-N-alkyl anilines via addition of Grignard reagents to aryl azides

Mono-N-alkyl anilines were obtained in high yields within a short reaction time when various aromatic azides were reacted with alkyl magnesium halides at room temperature.