66172-16-5

Basic information

• Product Name: Benzene, 4-azido-1,2-dichloro-
• CAS NO: 66172-16-5
• Molecular Formula: C6H3Cl2N3
• Molecular Weight: 188.016
• Mol File: 66172-16-5.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzene, 4-azido-1,2-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-azido-1,2-dichloro-(66172-16-5)
• EPA Substance Registry System: Benzene, 4-azido-1,2-dichloro-(66172-16-5)

Safety Data

• Hazardous Substances Data: 66172-16-5(Hazardous Substances Data)

Upstream product

• 405-02-7 1,2-dichloro-4-diazoniumbenzene tetrafluoroborate 
• 151169-75-4 3,4-dichlophenylboronic acid 
• 95-50-1 1,2-dichloro-benzene 
• 401797-02-2 2-(3,4-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 95-76-1 m,p-dichloroaniline 

Downstream Products

• 65245-88-7 C₁₃H₁₁Cl₂N₅ 
• 54962-86-6 (3,4-Dichloro-phenyl)-isopropyl-amine 
• 163071-47-4 5-azido-1-(3,4-dichlorophenyl)-4-(2-pyridyl)-1,2,3-triazole 
• 66172-29-0 2-(3,4-dichloro-phenyl)-5-(2,2,2-trifluoro-1-trifluoromethyl-ethylidene)-2,5-dihydro-[1,2,3,4]thiatriazole 
• 1325724-92-2 1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-carbaldehyde 
• 1325725-23-2 1-(3,4-dichlorophenyl)-4-vinyl-1H-1,2,3-triazole 
• 338419-11-7 1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-yl-methanol 
• 1146220-09-8 C₁₄H₈Cl₂N₄O₂ 
• 129748-86-3 Isopropyl-carbamic acid 3-(3,4-dichloro-phenyl)-5-isopropylcarbamoyloxymethyl-3H-[1,2,3]triazol-4-ylmethyl ester 
• 129748-81-8 [3-(3,4-Dichloro-phenyl)-5-hydroxymethyl-3H-[1,2,3]triazol-4-yl]-methanol 
• 77721-65-4 C₁₃H₁₁Cl₂N₃ 

Relevant articles and documents

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Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO)

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO), which mediate kynurenine pathway of tryptophan degradation, have emerged as potential new targets in immunotherapy for treatment of cancer because of their critical role in immunosuppression in the tumor microenvironment. In this investigation, we report the structural optimization and structure-activity relationship studies of 1-phenyl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as a new class of IDO1/TDO dual inhibitors. Among all the obtained dual inhibitors, 1-(3-chloro-4-fluorophenyl)-6-fluoro-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione (38) displayed the most potent IDO1 and TDO inhibitory activities with IC50 (half-maximal inhibitory concentration) values of 5 nM for IDO1 and 4 nM for TDO. It turned out that compound 38 was not a PAINS compound. Compound 38 could efficiently inhibit the biofunction of IDO1 and TDO in intact cells. In LL2 (Lewis lung cancer) and Hepa1-6 (hepatic carcinoma) allograft mouse models, this compound also showed considerable in vivo anti-tumor activity and no obvious toxicity was observed. Therefore, 38 could be a good lead compound for cancer immunotherapy and deserving further investigation.