5515-16-2

Basic information

• Product Name: 2-(1-Methoxyethylidene)Malononitrile
• Synonyms: 2-(1-Methoxyethylidene)Malononitrile;Propanedinitrile, 2-(1-methoxyethylidene)-
• CAS NO: 5515-16-2
• Molecular Formula: C₆H₆N₂O
• Molecular Weight: 122.12464
• Mol File: 5515-16-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 110 °C(Press: 0.25 Torr)
• Appearance: /
• Density: 1.071±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(1-Methoxyethylidene)Malononitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Methoxyethylidene)Malononitrile(5515-16-2)
• EPA Substance Registry System: 2-(1-Methoxyethylidene)Malononitrile(5515-16-2)

Safety Data

• Hazardous Substances Data: 5515-16-2(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Solubility

Insoluble in water

Reactivity

Highly reactive

Uses

Organic synthesis (Michael acceptor), production of pharmaceuticals and agrochemicals, precursor in the synthesis of various compounds (including pharmaceutical intermediates)

Reaction types

Michael addition, Knoevenagel condensation, cyanoethylation

Applications

Development of new materials, building block for the synthesis of complex molecules.

Upstream product

• 186581-53-3 diazomethane 
• 5515-35-5 2-(1-hydroxy-ethylidene)malononitrile 
• 672-81-1 2-(methoxymethylene)malononitrile 
• 67-56-1 methanol 
• 93102-10-4 dicyano-1,1 propadiene 
• 93102-15-9 bis-(cyano) methylene-11 ethano-9,10 dihydro-9,10 anthracene 
• 78-39-7 Triethyl orthoacetate 
• 109-77-3 malononitrile 
• 1445-45-0 Trimethyl orthoacetate 
• 149-73-5 trimethyl orthoformate 
• 616-42-2 dimethylsulfite 
• 1187-11-7 acetylmalonodinitrile 

Downstream Products

• 108675-18-9 2-Cyan-3-<(benzyliminomethyl-λ⁶-sulfanyliden)amino>-3-methylacrylnitril 
• 108675-19-0 2-Cyan-3-<(dibenzylimino-λ⁶-sulfanyliden)amino>-3-methylacrylnitril 
• 107325-87-1 2-<1-(1-Methyl-5-phenyl-1λ⁴,4-thiazin-3-ylamino)ethyliden>malononitril-S-oxid 
• 107325-88-2 2-<1-(1-Methyl-5-p-tolyl-1λ⁴,4-thiazin-3-ylamino)ethyliden>malononitril-S-oxid 
• 107325-89-3 2-<1-<5-(4-Clorphenyl)-1-methyl-1λ⁴,4-thiazin-3-ylamino>ethyliden>malononitril-S-oxid 
• 107325-93-9 8-Amino-1,6-dimethyl-3-phenylpyrido<3,2-b>-1λ⁴,4-thiazin-7-carbonitril-1-oxid 
• 107325-94-0 8-Amino-1,6-dimethyl-3-p-tolylpyrido<3,2-b>-1λ⁴,4-thiazin-7-carbonitril-1-oxid 
• 107325-95-1 8-Amino-3-(4-chlorphenyl)-1,6-dimethylpyrido<3,2-b>-1λ⁴,4-thiazin-7-carbonitril-1-oxid 
• 104366-22-5 2-amino-4-methoxythiophene-3-carbonitrile 
• 21642-98-8 2-hydroxy-4-methoxypyridine-3-carbonitrile 
• 95689-38-6 1,1-dicyano-4-(N,N-dimethylamino)-2-methoxy-1,3-butadiene 
• 87412-84-8 4-amino-3-methyl-1-phenylpyrazolo<3,4-d>pyrimidine 
• 5346-58-7 4-amino-1,3-dimethyl-1H-pyrazolo<3,4-d>pyrimidine 
• 5399-44-0 3-methyl-4-amino-1H-pyrazolo[3,4-d]pyrimidine 

Relevant articles and documents

3-cyanopyrazolopyrimidine [1,5-a] derivative as well as preparation method and application thereof

The invention belongs to the field of chemical medicines and specifically relates to a 3-cyanopyrazolopyrimidine [1,5-a] derivative as well as a preparation method and application thereof. The invention provides the 3-cyanopyrazolopyrimidine [1,5-a] derivative, and the structure of the 3-cyanopyrazolopyrimidine [1,5-a] derivative is shown as a formula I. The invention further provides the preparation method and the application of the 3-cyanopyrazolopyrimidine [1,5-a] derivative. (The formula I is shown in the description).

BICYCLIC HETEROCYCLES AS FGFR INHIBITORS

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Transesterification of trimethyl orthoacetate: An efficient protocol for the synthesis of 4-alkoxy-2-aminothiophene-3-carbonitriles

A facile one-pot method is reported for the synthesis of 4-alkoxy-2-aminothiophene-3-carbonitriles. Transesterification of trimethylorthoacetate technique allowed introducing alkoxy substituents into 2-aminothiophene ring system. Diverse alkoxy substituents could be introduced efficiently by using this methodology. Further the synthesis of some of new 4-alkylamino-2-aminothiophenes is also reported.