55162-34-0

Basic information

• Product Name: 4-BROMOPHENYL 2-CHLOROETHYL ETHER
• Synonyms: 2-(4-BROMOPHENOXY)ETHYL CHLORIDE;4-(2-CHLOROETHOXY)-BROMOBENZENE;4-BROMOPHENYL 2'-CHLOROETHYL ETHER;4-BROMOPHENYL 2-CHLOROETHYL ETHER;1-bromo-4-(2-chloroethoxy)benzene;2-Chloroethyl 4-bromophenyl ether;Ai3-07826;Benzene, L-bromo-4-(2-chloroethoxy)-
• CAS NO: 55162-34-0
• Molecular Formula: C₈H₈BrClO
• Molecular Weight: 235.51
• EINECS: 259-507-2
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;Chlorine Compounds;Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 55162-34-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 55-57 °C(lit.)
• Boiling Point: 279.8 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: white powder or crystals
• Density: 1.495 g/cm³
• Vapor Pressure: 0.00666mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 4-BROMOPHENYL 2-CHLOROETHYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOPHENYL 2-CHLOROETHYL ETHER(55162-34-0)
• EPA Substance Registry System: 4-BROMOPHENYL 2-CHLOROETHYL ETHER(55162-34-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 55162-34-0(Hazardous Substances Data)

Usage

General Description

4-Bromophenyl 2-chloroethyl ether, also known as 2-Chloroethyl 4-bromophenyl ether, is a chemical compound that is used in the synthesis of pharmaceuticals and agrochemicals. It is a versatile building block for the development of various organic compounds due to its reactivity and ability to undergo substitution reactions. This chemical is a clear, colorless liquid with a slightly sweet odor and is insoluble in water. It is important to handle this compound with care as it is considered to be a hazardous substance with potential health and environmental risks.

InChI:InChI=1/C8H8BrClO/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4H,5-6H2

Upstream product

• 106-41-2 4-bromo-phenol 
• 107-06-2 1,2-dichloro-ethane 
• 34743-88-9 2-(4-bromophenoxy)ethanol 
• 622-86-6 2-chloroethoxybenzene 
• 80-41-1 2-chloroethyl tosylate 
• 107-04-0 1-Bromo-2-chloroethane 

Downstream Products

• 90296-22-3 diethyl 2-<2-(p-bromophenoxy)ethyl>malonate 
• 25836-85-5 N-<2-(4-Brom-phenoxy)-ethyl>-anilin 
• 252044-23-8 4-(2-chloro-ethoxy)-phenylboronic acid 
• 1005-61-4 4-bromophenyl vinyl ether 
• 64009-57-0 β-[2-(4-bromophenoxy)ethyl]-2,4-dichlorobenzeneethanol 
• 64009-35-4 4-(4-Bromo-phenoxy)-2-(2,4-dichloro-phenyl)-butyric acid methyl ester 
• 448967-20-2 3-[2-(4-Bromo-phenoxy)-ethyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidine-6-carboxylic acid 3-methoxy-benzylamide 
• 877995-77-2 1-(4-bromophenoxy)-2-(2,6-dichloro-4-methylphenoxy)ethane 
• 1160848-98-5 5-[4-(2-chloroethoxy)phenyl]-6-methyl-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile 
• 1160918-14-8 5-{(E)-2-[4-(2-chloroethoxy)phenyl]vinyl}-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile 
• 1160918-16-0 4-[(4-methyl-1H-indol-5-yl)amino]-5-[(E)-2-{4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}vinyl]nicotinonitrile 
• 1295647-29-8 (3,4-dimethyl-2-thioxo-2,3-dihydro-thiazol-5-yl)-{3-[2-(4-bromophenoxy)-ethylsulfanyl]-diazirin-1-yl}-methanone 
• 1081-73-8 1-[2-(4-bromophenoxy)ethyl]pyrrolidine 
• 250600-43-2 1-[2-(4-Bromophenoxy)ethyl]-1H-imidazole 

Relevant articles and documents

Synthesis of N-Alkyl Anilines from Arenes via Iron-Promoted Aromatic C-H Amination

We report both an intermolecular C-H amination of arenes to access N-methylanilines and an intramolecular variant for the synthesis of tetrahydroquinolines. A newly developed, highly electrophilic aminating reagent was key for the direct synthesis of unprotected N-methylanilines from simple arenes. The reactions display a broad functional group tolerance and employ catalytic amounts of a benign iron salt under mild reaction conditions.

Practical synthesis of a renin inhibitor via a diastereoselective dieckmann cyclization

A scalable synthesis of a potent renin inhibitor (1) is described. The absolute stereochemistry is set via an unprecedented diastereoselective Dieckmann cyclization directed by a remote chiral protecting group. This transformation enables preparation of chiral 1,3-[3.3.1]-diazabicyclononenes by desymmetrization of alkyl-esters, with selectivities ranging from 4 to 17:1.

NOVEL CASE OF RENIN INHIBITORS

The present invention relates to piperidine-based renin inhibitor compounds having carboxylate or carboxylic acid terminal groups. The disclosed low molecular weight, orally active renin inhibitors are of non-peptide nature and have long duration of action. The compounds can be used in the treatment of cardiovascular events and renal insufficiency.