552-72-7

Basic information

• Product Name: 2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanol
• Synonyms: 2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanol;Lobeline HCl EP Impurity C;Lobeline EP Impurity C
• CAS NO: 552-72-7
• Molecular Formula: C₂₂H₂₉NO₂
• Molecular Weight: 339.47
• Mol File: 552-72-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 150°
• Boiling Point: 475.43°C (rough estimate)
• Flash Point: 242.3°C
• Appearance: /
• Density: 1.0751 (rough estimate)
• Refractive Index: 1.5614 (estimate)
• PKA: 14.04±0.20(Predicted)
• CAS DataBase Reference: 2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanol(552-72-7)
• EPA Substance Registry System: 2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanol(552-72-7)

Safety Data

• RIDADR: 1544
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 552-72-7(Hazardous Substances Data)

Usage

General Description

2-[6-(2-hydroxy-2-phenyl-ethyl)-1-methyl-2-piperidyl]-1-phenyl-ethanol is a complex chemical compound with a long and specific name. It is a type of phenylethanolamine that contains a piperidyl ring and a phenyl ring, as well as a hydroxyethyl and a methyl group. The chemical structure suggests that it may have psychoactive properties or be used as a pharmaceutical agent. It is likely to have a diverse range of potential applications, including in medicine, pharmacology, and chemistry, given its complex structure and the presence of various functional groups. Further research and testing would be necessary to fully understand and harness the properties and potential uses of this chemical compound.

Upstream product

• 6168-88-3 2,2′-((2,6)-1-methylpiperidine-2,6-diyl)bis(1-phenylethanone) hydrochloride 
• 579-21-5 Lobelanine 
• 119673-97-1 lobelanine hydrogensulfate 
• 80-48-8 methyl p-toluene sulfonate 
• 1070913-25-5 C₂₆H₃₅NO₄ 
• 1146626-27-8 lobelanidine diacetate 

Downstream Products

• 98-86-2 acetophenone 
• 579-21-5 Lobelanine 
• 950194-38-4 C₂₅H₃₃NO₃ 
• 950194-41-9 C₂₅H₃₃NO₃ 
• 950194-40-8 (S)-2-[(2R,6S)-6-(2-propionyloxy-2-phenylethyl)-1-methylpiperidin-2-yl]-1-phenylethanone 
• 134-63-4 Lobeline hydrochloride 
• 864969-12-0 cis-2,6-di-trans-styrlpiperidine hydrochloric salt 
• 864969-22-2 trans-2,6-di-trans-styrlpiperidine hydrochloric salt 
• 90-69-7 lobeline 
• 1146626-22-3 lobelanidine monoacetate 
• 1146626-27-8 lobelanidine diacetate 

Relevant articles and documents

Preparation method of optically pure lobeline hydrochloride and enantiomer thereof

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of optically pure lobeline hydrochloride and an enantiomer of the optically pure lobeline hydrochloride. According to the method, benzoylacetic acid, methylamine hydrochloride and glutaraldehyde are used as raw materials, and a target product can be prepared through condensation, reduction, acylation, resolution, oxidation and hydrolysis reactions in sequence. According to the method, meso-racemic lobeline is derived into raceme through acylation by adopting a desymmetry strategy, so that conditions are created for further resolution, and the use of a chiral catalyst which is high in price and tedious in preparation is avoided. In the splitting step, the product is filtered, the obtained filtrate is subjected to hydrolysis and other treatments to obtain an intermediate compound II, and the intermediate compound II can be recycled, so that the process cost is greatly saved; and moreover, the whole preparation process flow is simple to operate, mild in condition, high in optical purity of the product and very suitable for large-scale industrial production.

Pd-catalyzed enantioselective aerobic oxidation of secondary alcohols: Applications to the total synthesis of alkaloids

Enantioselective syntheses of the alkaloids (-)-aurantioclavine, (+)-amurensinine, (-)-lobeline, and (-)- and (+)-sedamine are described. The syntheses demonstrate the effectiveness of the Pd-catalyzed asymmetric oxidation of secondary alcohols in diverse contexts and the ability of this methodology to set the absolute configuration of multiple stereocenters in a single operation. The utility of an aryne C-C insertion reaction in accessing complex polycyclic frameworks is also described.

2,6-disubstituted piperidines as modulators of nicotinic acetylcholine receptor mediated neurotransmitter release, uptake and storage

Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder or for a CNS disease or pathology having the following formulas: