6168-88-3

Basic information

• Product Name: cis-2,2'-(1-methylpiperidine-2,6-diyl)bis[1-phenylethan-1-one] hydrochloride
• Synonyms: cis-2,2'-(1-methylpiperidine-2,6-diyl)bis[1-phenylethan-1-one] hydrochloride;cis-2,2'-(1-Methyl-2,6-piperidinediyl)bis[1-phenylethanone]·Hydrochloride;2-(1-methyl-6-phenacylpiperidin-1-ium-2-yl)-1-phenylethanone chloride
• CAS NO: 6168-88-3
• Molecular Formula: C₂₂H₂₅NO₂*ClH
• Molecular Weight: 371.90034
• EINECS: 228-212-0
• Mol File: 6168-88-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: cis-2,2'-(1-methylpiperidine-2,6-diyl)bis[1-phenylethan-1-one] hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: cis-2,2'-(1-methylpiperidine-2,6-diyl)bis[1-phenylethan-1-one] hydrochloride(6168-88-3)
• EPA Substance Registry System: cis-2,2'-(1-methylpiperidine-2,6-diyl)bis[1-phenylethan-1-one] hydrochloride(6168-88-3)

Safety Data

• RIDADR: 1544
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 6168-88-3(Hazardous Substances Data)

Usage

General Description

The chemical "cis-2,2'-(1-methylpiperidine-2,6-diyl)bis[1-phenylethan-1-one] hydrochloride" is a compound that belongs to the class of bis-ketones. It is a hydrochloride salt with a molecular formula of C26H29NO.HCl. cis-2,2'-(1-methylpiperidine-2,6-diyl)bis[1-phenylethan-1-one] hydrochloride has potential applications in the field of medicinal chemistry, specifically as a potential therapeutic agent for the treatment of various medical conditions. Further research and testing are necessary to fully understand the properties and potential uses of this chemical compound.

Upstream product

• 614-20-0 3-oxo-3-phenylpropionic acid 
• 593-51-1 methylamine hydrochloride 
• 111-30-8 Glutaraldehyde 
• 579-21-5 2,2′-(1-methylpiperidine-2,6-diyl)bis(1-phenylethanone) 

Downstream Products

• 552-72-7 NSC 95097 
• 552-72-7 (2RS)-2r,6t-bis-((Ξ)-β-hydroxy-phenethyl)-1-methyl-piperidine 
• 950194-38-4 C₂₅H₃₃NO₃ 
• 950194-41-9 C₂₅H₃₃NO₃ 
• 950194-40-8 (S)-2-[(2R,6S)-6-(2-propionyloxy-2-phenylethyl)-1-methylpiperidin-2-yl]-1-phenylethanone 
• 134-63-4 Lobeline hydrochloride 
• 579-21-5 Lobelanine 
• 579-21-5 2,2′-((2RS,6RS)-1-methylpiperidine-2,6-diyl)bis(1-phenylethanone) 

Relevant articles and documents

Thermodynamic epimeric equilibration and crystallisation-induced dynamic resolution of lobelanine, norlobelanine and related analogues

The step-economical synthesis of lobelanine involving a ring closing double aza-Michael (RCDAM) reaction is revisited and successfully extended to the synthesis of various configurationally more stable analogues. Owing to the presence of a configurationally labile β-aminoketone subunit, lobelanine is prone to self-catalyze mutarotation in solution. Through the synthesis of original lobelanine analogues, we studied the influence of (i) the size of the central heterocycle, (ii) the bulkiness of the nitrogen protecting group, and (iii) the phenacyl arm substituent on the thermodynamic equilibrium and its displacement by crystallisation-induced dynamic resolution (CIDR). We demonstrated that fine structural tuning combined with optimized CIDR conditions favours the first efficient diastereoselective synthesis of lobelanine's analogues.