5521-39-1

Basic information

• Product Name: 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol
• Synonyms: 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol;4-[4-(2-Hydroxyethyl)piperazin-1-yl]aniline;AKOS BB1150;OTAVA-BB 7020694390;VITAS-BB TBB005536;2-(4-(4-Aminophenyl)
• CAS NO: 5521-39-1
• Molecular Formula: C₁₂H₁₉N₃O
• Molecular Weight: 221.3
• Mol File: 5521-39-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 435.8°C at 760 mmHg
• Flash Point: 217.4°C
• Appearance: /
• Density: 1.163g/cm³
• Vapor Pressure: 2.28E-08mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol(5521-39-1)
• EPA Substance Registry System: 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol(5521-39-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5521-39-1(Hazardous Substances Data)

Usage

General Description

2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol is a chemical compound that belongs to the class of organic compounds known as benzenoids. The chemical structure consists of a benzene ring connected to a piperazine ring and a hydroxyl group (-OH) attached to an ethyl group. It contains an amino group (-NH2) on the benzene ring. 2-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-ol plays a significant role in the field of biochemistry, primarily in the creation of various drugs due to its reactivity and versatility. Its detailed properties including solubility, stability, and reactivity are determined by its specific structure. Safety measures should be taken during its handling and storage, as it may possess potential risks based on its nature and properties, though specific data should be referred to for accurate information.

InChI:InChI=1/C12H19N3O/c13-11-1-3-12(4-2-11)15-7-5-14(6-8-15)9-10-16/h1-4,16H,5-10,13H2

Upstream product

• 5521-38-0 2-(4-(4-nitrophenyl)piperazin-1-yl)ethan-1-ol 
• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 1229976-54-8 3-(2,6-dichlorophenyl)-7-({4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}amino)-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one 
• 1232816-06-6 2-{4-[4-(7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino)-phenyl]-piperazin-1-yl}-ethanol 

Relevant articles and documents

WEE1 inhibitors as well as preparation and application thereof

The invention relates to WEE1 inhibitors as well as preparation and application thereof. The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates, polymorphs or isomers thereof, and their use in the preparation of medicaments for the treatment of diseases associated with WEE1 activity.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS

The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.