5521-38-0

Basic information

• Product Name: 2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL
• Synonyms: 2-[4-(4-NITROPHENYL)PIPERAZIN-1-YL]ETHANOL;2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL;2-[4-(4-Nitrophenyl)-1-piperazinyl]ethanol, 97%;2-(4-(4-Nitrophenyl)
• CAS NO: 5521-38-0
• Molecular Formula: C₁₂H₁₇N₃O₃
• Molecular Weight: 251.28
• Mol File: 5521-38-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 97-99°C
• Boiling Point: 445.6±45.0 °C(Predicted)
• Appearance: /Solid
• Density: 1.258±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.96±0.10(Predicted)
• CAS DataBase Reference: 2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL(5521-38-0)
• EPA Substance Registry System: 2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL(5521-38-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5521-38-0(Hazardous Substances Data)

Usage

General Description

2-[4-(4-NITROPHENYL)PIPERAZINO]-1-ETHANOL, also known as NPP, is a chemical compound with a molecular formula C14H20N2O3. It is a member of the piperazine family and contains a nitrophenyl group. NPP is commonly used in laboratory research as a ligand for studying serotonin receptors and has potential applications in pharmaceutical research for developing new drugs targeting these receptors. The compound has also been studied for its potential use in anti-anxiety medications. However,

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 350-46-9 4-Fluoronitrobenzene 
• 6269-89-2 1-(4-Nitrophenyl)piperazine 
• 540-51-2 2-bromoethanol 
• 57938-64-4 N-(2-hydroxyethyl)piperazine hydrochloride 

Downstream Products

• 5521-39-1 2-(4-(4-aminophenyl)piperazin-1-yl)ethan-1-ol 
• 710272-54-1 1-(2-chloroethyl)-4-(4-nitrophenyl)piperazine 
• 1262048-27-0 2-[4-(4-nitrophenyl)piperazin-1-yl]ethyl methanesulfonate 

Relevant articles and documents

WEE1 inhibitors as well as preparation and application thereof

The invention relates to WEE1 inhibitors as well as preparation and application thereof. The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates, polymorphs or isomers thereof, and their use in the preparation of medicaments for the treatment of diseases associated with WEE1 activity.

Design, synthesis and biological evaluation of novel 7-amino-[1,2,4]triazolo[4,3-f]pteridinone, and 7-aminotetrazolo[1,5-f]pteridinone derivative as potent antitumor agents

To develop novel therapeutic agents with anticancer activities, two series of novel 7-amino-[1,2,4]triazolo[4,3-f]pteridinone, and 7-aminotetrazolo[1,5-f]pteridinone derivatives were designed and synthesized. All compounds were tested for anti-proliferative activities against five cancer cell lines. The structure-activity relationships (SARs) studies were conducted through the variation in two regions, the moiety of A ring and the terminal aniline B on pteridinone core. 1-Methyl-1,2,4-triazole derivative L7 with 2,6-dimethylpiperazine showed the most potent antiproliferative activity against A549, PC-3, HCT116, MCF-7 and MDA-MB-231 cell lines with IC50 values of 0.16 μM, 0.30 μM, 0.51 μM, 0.30 μM, and 0.70 μM, respectively. Combined with the results of the molecular docking and enzymatic studies, the PLK1 was very likely to be one of the drug targets of compound L7. Furthermore, to clarify the anticancer mechanism of compound L7, further explorations in the bioactivity were conducted. The results showed that compound L7 obviously inhibited proliferation of A549 cell lines, induced a great decrease in mitochondrial membrane potential leading to apoptosis of cancer cells, suppressed the migration of tumor cells, and arrested G1 phase of A549 cells.

PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS

The present invention provides kinase inhibitors with anti-proliferative activity comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof. In addition, the invention provides methods for making novel compounds and methods for using the compounds.