552866-98-5

Basic information

• Product Name: 4-FLUORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE
• Synonyms: 4-FLUORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE;4-FLUORO-2,3-DIHYDRO-1H-INDOLE HCL;4-fluoroindoline;2,3-Dihydro-4-fluoro-1H-indole;1H-Indole,4-fluoro-2,3-dihydro-;4-Fluoro-2,3-dihydro-indole
• CAS NO: 552866-98-5
• Molecular Formula: C₈H₈FN
• Molecular Weight: 173.6151632
• Mol File: 552866-98-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 215.7 °C at 760 mmHg
• Flash Point: 84.2 °C
• Appearance: /
• Density: 1.154 g/cm³
• Vapor Pressure: 0.146mmHg at 25°C
• Refractive Index: 1.538
• PKA: 4.29±0.20(Predicted)
• CAS DataBase Reference: 4-FLUORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE(552866-98-5)
• EPA Substance Registry System: 4-FLUORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE(552866-98-5)

Safety Data

• Hazardous Substances Data: 552866-98-5(Hazardous Substances Data)

Usage

General Description

4-FLUORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE, also known as fluoroindole, is a chemical compound that is commonly used in research and pharmaceutical applications. It is a derivative of the indole molecule, which is commonly found in many natural products. 4-FLUORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE is frequently utilized as a building block in the synthesis of various pharmaceutical drugs and as a reference standard in analytical chemistry. The hydrochloride salt form of this compound enhances its solubility in water, making it more practical for certain applications. 4-FLUORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE is known for its potential biological activity and is often used in drug discovery and development processes for various therapeutic purposes.

InChI:InChI=1/C8H8FN/c9-7-2-1-3-8-6(7)4-5-10-8/h1-3,10H,4-5H2

Upstream product

• 387-43-9 4-fluoroindole 
• 344790-94-9 1-(2-(2-fluoro-6-nitrophenyl)vinyl)pyrrolidine 
• 769-10-8 1-fluoro-2-methyl-3-nitrobenzene 

Downstream Products

• 915953-60-5 C₁₉H₂₃N₂F 
• 915953-65-0 C₁₉H₂₂N₂F₂ 
• 915953-69-4 C₁₉H₂₁N₂F 
• 915953-78-5 C₁₈H₁₉FN₂ 
• 860024-83-5 1-(4-fluoroindolin-1-yl)ethanone 
• 1037075-45-8 1,1-dimethylethyl 4-fluoro-2,3-dihydro-1H-indole-1-carboxylate 
• 1337533-31-9 1,1-dimethylethyl 5-bromo-4-fluoro-2,3-dihydro-1H-indole-1-carboxylate 
• 1337532-29-2 GSK2656157 
• 1493759-82-2 3-(4-cyclopentylphenylmethyl)-4-fluoro-1-(β-D-glucopyranosyl)indole 
• 903550-99-2 1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-fluoroindol-3-yl-4-ethylphenylketone 
• 903551-07-5 C₃₁H₃₂FNO₁₁ 
• 1493759-02-6 C₂₉H₂₇ClFNO₁₀ 
• 1493759-15-1 C₃₄H₃₆FNO₁₀ 
• 903551-00-8 1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-(4-ethylphenylmethyl)-4-fluoroindole 

Relevant articles and documents

PERK INHIBITING INDOLINYL COMPOUNDS

Provided herein are compounds of formula (I), compositions, and methods useful for inhibiting PERK and for treating related conditions diseases, and disorders, wherein Q is selected from (Ia), (Ib) ou (Ic).

Synthesis and Photophysical Study of Heteropolycyclic and Carbazole Motif: Nickel-Catalyzed Chelate-Assisted Cascade C-H Activations/Annulations

Herein, nickel-catalyzed synthesis of polyarylcarbazole through sequential C-H bond activations has been described. Regioselective indole C2/C3 functionalization has been achieved in the presence of indole C7-H, which is quite challenging. In addition, this approach also gives easy access to building a heteropolycyclic motif through C6/C7 C-H functionalization of indoline. This methodology is not limited to aromatic internal alkynes as coupling partners; aliphatic alkynes have also shown good tolerance. Notably, during the optimization the catalytic enhancement with sodium iodide as an additive has been observed. We have also studied the photophysical properties of these highly conjugated molecules.

5-SULFAMOYL-2-HYDROXYBENZAMIDE DERIVATIVES

The invention is directed to substituted salicylamide derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, the treatment of HIV, autoimmune diseases, infections, atherosclerosis, and ischemia–reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.