769-10-8 Usage
Description
2-Fluoro-6-nitrotoluene is an organic compound with the molecular formula C7H6FNO2. It is a colorless to light yellow liquid that is characterized by the presence of a fluorine atom at the 2nd position and a nitro group at the 6th position on the toluene ring. 2-Fluoro-6-nitrotoluene is known for its reactivity and is commonly used as an intermediate in the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
2-Fluoro-6-nitrotoluene is used as a synthetic intermediate for the preparation of 4-fluoroindole via the Leimgruber-Batcho procedure. This is significant in the pharmaceutical industry as 4-fluoroindole and its derivatives have potential applications in the development of new drugs, particularly those targeting the central nervous system.
Used in Chemical Synthesis:
2-Fluoro-6-nitrotoluene is also used as a starting material in the synthesis of various organic compounds. For instance, it can undergo reduction in the presence of stannous chloride, followed by benzoylation to yield N-(3-fluoro-o-tolyl)benzamide. Additionally, it can react with concentrated nitric acid at 100°C to produce 2-fluoro-6-nitrobenzoic acid, which can be further utilized in the synthesis of other compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 769-10-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,6 and 9 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 769-10:
(5*7)+(4*6)+(3*9)+(2*1)+(1*0)=88
88 % 10 = 8
So 769-10-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H6FNO2/c1-5-6(8)3-2-4-7(5)9(10)11/h2-4H,1H3
769-10-8Relevant articles and documents
4-Substituted indazoles as new inhibitors of neuronal nitric oxide synthase
Boulouard, Michel,Schumann-Bard, Pascale,Butt-Gueulle, Sabrina,Lohou, Elodie,Stiebing, Silvia,Collot, Valerie,Rault, Sylvain
, p. 3177 - 3180 (2008/02/04)
A series of halo-1-H-indazoles has been synthesized and evaluated for its inhibitory activity on neuronal nitric oxide synthase. Introduction of bromine at the C4 position of the indazole ring system provided a compound almost as potent as the reference compound, that is, 7-nitroindazole (7-NI). The importance of position 4 is further demonstrated by the synthesis and pharmacological evaluation of the 4-nitroindazole which was also a potent inhibitor of NOS activity. These compounds also exhibited in vivo NOS inhibitory activity, as attested by potent antinociceptive effects following systemic administration.
Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
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, (2008/06/13)
Optionally substituted 1,2,3,5-tetrahydroimidazol[2,1-b]-quinazolin-2-ones and 6-[H]-1,2,3,4-tetrahydropyrimidol[2,1-b]quinazolin-2-ones or the pharmaceutically acceptable salts thereof are compounds useful as blood platelet anti-aggregative and/or antihypertensive and/or bronchodilator agents in mammals, including humans.
The synthesis of ortho-substituted 2-diethylaminoethyl benzoates as potential local anaesthetics.
THOMAS,CANTY
, p. 587 - 596 (2007/10/05)
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