55288-06-7

Basic information

• Product Name: L-Tyrosine, N-L-phenylalanyl-, methyl ester
• CAS NO: 55288-06-7
• Molecular Formula: C19H22N2O4
• Molecular Weight: 342.395
• Mol File: 55288-06-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Tyrosine, N-L-phenylalanyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, N-L-phenylalanyl-, methyl ester(55288-06-7)
• EPA Substance Registry System: L-Tyrosine, N-L-phenylalanyl-, methyl ester(55288-06-7)

Safety Data

• Hazardous Substances Data: 55288-06-7(Hazardous Substances Data)

Upstream product

• 1080-06-4 L-Tyr-OMe 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 127802-97-5 (S)-O-allyl-tyrosine methyl ester 
• 147363-23-3 methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[4-(prop-2-en-1-yloxy)phenyl]-propanoate 
• 90508-20-6 N-allyloxycarbonyl-(S)-phenylalanate 
• 63-91-2 L-phenylalanine 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 66076-54-8 N-tert-butyloxycarbonyl-L-phenylalanine-L-tyrosine methyl ester 
• 60-18-4 L-tyrosine 
• 3417-91-2 L-tyrosine methyl ester HCl 

Downstream Products

• 5147-17-1 (3S,6S)-3-benzyl-6-(4-hydroxybenzyl)piperazine-2,5-dione 

Relevant articles and documents

Histamine H3 receptor antagonists with peptidomimetic (keto)piperazine structures to inhibit Aβ oligomerisation

Alzheime?s disease (AD) is the most prominent neurodegenerative disorder with high medical need. Protein-protein-interactions (PPI) interactions have a critical role in AD where β-amyloid structures (Aβ) build toxic oligomers. Design of disease modifying multi target directed ligand (MTDL) has been performed, which disable PPI on the one hand and on the other hand, act as procognitive antagonists at the histamine H3 receptor (H3R). The synthetized compounds are structurally based on peptidomimetic amino acid-like structures mainly as keto, diketo-, or acyl variations of a piperazine moiety connected to an H3R pharmacophore. Most of them showed low nanomolar affinities at H3R and some with promising affinity to Aβ-monomers. The structure–activity relationships (SAR) described offer new possibilities for MTDL with an optimized profile combining symptomatic and potential causal therapeutic approaches in AD.

A mild copper catalyzed method for the selective deprotection of aryl allyl ethers

Copper boryl reagents enable the selective cleavage of aryl allyl ethers to the corresponding phenols in good to moderate yields.

Antibody catalyzed modification of amino acids. Efficient hydrolysis of tyrosine benzoate

Esterase antibody 522c2, the first example of a catalytic antibody specifically programmed to control the reactivity of functional groups on the side chain of tyrosine, accelerates the hydrolysis of benzoate esters of L-tyrosine and tyrosine-containing dipeptides by a factor of 104 and is moderately active against other benzoate esters.