66076-54-8

Basic information

• Product Name: L-Tyrosine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, methyl ester
• CAS NO: 66076-54-8
• Molecular Formula: C24H30N2O6
• Molecular Weight: 442.512
• Mol File: 66076-54-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: L-Tyrosine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(66076-54-8)
• EPA Substance Registry System: L-Tyrosine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(66076-54-8)

Safety Data

• Hazardous Substances Data: 66076-54-8(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 60-18-4 L-tyrosine 
• 1080-06-4 L-Tyr-OMe 
• 81000-39-7 (S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanethioic S-acid 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 66076-38-8 (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-3-(4-hydroxyphenyl)propanoic acid 
• 55288-06-7 H-Phe-Tyr-OMe 
• 5147-17-1 (3S,6S)-3-benzyl-6-(4-hydroxybenzyl)piperazine-2,5-dione 
• 70930-22-2 Phe-Tyr methyl ester trifluoroacetate 
• 91474-83-8 Boc-Asp(OBzl)-Arg(Mds)-Phe-Tyr-Gly-OH 
• 91474-82-7 Z-Arg(Mds)-Phe-Tyr-Gly-OBzl 
• 91474-73-6 Boc-Phe-Tyr-Gly-Met-Met-NH₂ 
• 91474-74-7 H-Phe-Tyr-Gly-Met-Met-NH₂ 
• 91474-79-2 Boc-Phe-Tyr-Gly-OBzl 
• 91474-59-8 Boc-Phe-Tyr-Gly-NHNH₂ 
• 91474-58-7 Boc-Phe-Tyr-Gly-OMe 
• 91474-80-5 H-Phe-Tyr-Gly-OBzl 
• 91474-88-3 H-Asp(OBzl)-Arg(Mds)-Phe-Tyr-Gly-Met-Met-NH₂*HCl 
• 91474-85-0 Boc-Asp(OBzl)-Arg(Mds)-Phe-Tyr-Gly-Met-Met-NH₂ 

Relevant articles and documents

Transition-metal ion-mediated morphological transformation of pyridine-based peptide nanostructures

Inspired by natural metallopeptides, we have rationally designed two pyridine-conjugated short peptides. These two peptide conjugates formed a pair of constitutional isomers that helped us describe their structure-function relationship. Both the isomers consisted of an equal number of aromatic amino acid residues, but shuffling was observed in the position of two key amino acids, viz; tyrosine and phenylalanine, which brought a remarkable change in their self-assembling behavior. The presence of specific functional groups and chemical diversity in both conjugates made them very active towards metal coordination. Both the constitutional isomers adopted different pathways of self-assembly, which could be further controlled or transformed by the use of transition metal ions. Interestingly, it was observed that the metal ions could precisely control the morphology of these metallopeptide nanostructures and make them more stable. Therefore, such artificial metallopeptides possess remarkable advantages over the natural counterparts primarily due to their tailor-made chemical structures.

Tyrosine-Specific Modification via a Dearomatization-Rearomatization Strategy: Access to Azobenzene Functionalized Peptides

Azobenzene functionalized peptides are of great importance in photoresponsive biosystems and photopharmacology. Herein, we report an efficient approach to prepare azobenzene functionalized peptides through late-stage modification of tyrosine-containing peptides using a dearomatization-rearomatization strategy. This approach shows good chemoselectivity and site selectivity as well as sensitive group tolerance to various peptides. This method enriches the postsynthetic modification toolbox of peptides and has great potential to be applied in medicinal chemistry and chemical biology.

Marine natural occurring 2,5-diketopiperazines: Isolation, synthesis and optical properties

Seven 2,5-diketopiperazines (DKPs) were isolated from the Fijian marine sponge Acanthella cavernosa. NMR and circular dichroism (CD) comparison with synthetic L-L DKPs allowed us to determine unambiguously the L-L absolute configuration of the natural DKPs. This work initiated the setting up of an optical properties database of natural DKPs, including specific rotation and CD.