55316-36-4Relevant articles and documents
Imidazopyridine CB2 agonists: Optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy
Trotter, B. Wesley,Nanda, Kausik K.,Burgey, Christopher S.,Potteiger, Craig M.,Deng, James Z.,Green, Ahren I.,Hartnett, John C.,Kett, Nathan R.,Wu, Zhicai,Henze, Darrell A.,Penna, Kimberly Della,Desai, Reshma,Leitl, Michael D.,Lemaire, Wei,White, Rebecca B.,Yeh, Suzie,Urban, Mark O.,Kane, Stefanie A.,Hartman, George D.,Bilodeau, Mark T.
scheme or table, p. 2354 - 2358 (2011/06/17)
A new series of imidazopyridine CB2 agonists is described. Structural optimization improved CB2/CB1 selectivity in this series and conferred physical properties that facilitated high in vivo exposure, both centrally and peripherally. Administration of a h