5543-33-9

Basic information

• Product Name: (3-phenyl-1,2,4-oxadiazol-5-yl)methanol
• Synonyms: (3-phenyl-1,2,4-oxadiazol-5-yl)methanol;(3-phenyl-1,2,4-oxadiazol-5-yl)methanol(SALTDATA: FREE)
• CAS NO: 5543-33-9
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.174
• Mol File: 5543-33-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 343.599°C at 760 mmHg
• Flash Point: 161.603°C
• Appearance: /
• Density: 1.279g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: (3-phenyl-1,2,4-oxadiazol-5-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-phenyl-1,2,4-oxadiazol-5-yl)methanol(5543-33-9)
• EPA Substance Registry System: (3-phenyl-1,2,4-oxadiazol-5-yl)methanol(5543-33-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5543-33-9(Hazardous Substances Data)

Usage

General Description

(3-phenyl-1,2,4-oxadiazol-5-yl)methanol is a chemical compound with the molecular formula C9H7N3O2. It is a white solid with a molecular weight of 189.17 g/mol. (3-phenyl-1,2,4-oxadiazol-5-yl)methanol is a derivative of oxadiazole and is commonly used as a building block in organic synthesis. It has potential applications in the pharmaceutical industry for the development of new drugs and in the field of material science for the design of novel materials. Additionally, (3-phenyl-1,2,4-oxadiazol-5-yl)methanol may also have utility as a fluorescent probe in biological studies and as a ligand in coordination chemistry. Overall, this compound has versatile uses and potential for further research and development.

InChI:InChI=1/C9H8N2O2/c12-6-8-10-9(11-13-8)7-4-2-1-3-5-7/h1-5,12H,6H2

Upstream product

• 5543-31-7 5-acetoxymethyl-3-phenyl-[1,2,4]oxadiazole 
• 1822-94-2 5-(chloromethyl)-3-phenyl-1,2,4-oxadiazole 
• 623-50-7 ethyl 2-hydroxyacetate 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 1544566-03-1 N-(2-((tert-butyldimethylsilyl)oxy)acetoxy)benzimidamide 
• 942-87-0 N'-acetoxybenzimidamide 
• 67226-76-0 (tert-butyldimethylsiloxy) acetic acid tert-butyldimethylsilyl ester 

Relevant articles and documents

Construction of 3,5-substituted 1,2,4-oxadiazole rings triggered by tetrabutylammonium hydroxide: A highly efficient and fluoride-free ring closure reaction of O-acylamidoximes

Tetrabutylammonium hydroxide (TBAH) is an efficient and mild alternative to tetrabutylammonium fluoride (TBAF) for base catalyzed cyclizations of 1,2,4-oxadiazoles from O-acylamidoximes. For most 3,5-substituted 1,2,4-oxadiazoles the reactions were dramatically accelerated by addition of 0.1 equiv of TBAH at room temperature. This method was also more generally applicable allowing for a wider range of substrates. Additionally, due to the absence of fluoride, TBAH will not result in corrosion of reactor vessels and therefore is better suited for large-scale synthesis.

Metabolities of 3-phenyl-5-methyl-1,2,4-oxadiazole (PMO) in rats, dogs, and mice.

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