5543-33-9

Basic information

• Product Name: (3-phenyl-1,2,4-oxadiazol-5-yl)methanol
• Synonyms: (3-phenyl-1,2,4-oxadiazol-5-yl)methanol;(3-phenyl-1,2,4-oxadiazol-5-yl)methanol(SALTDATA: FREE)
• CAS NO: 5543-33-9
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.174
• Mol File: 5543-33-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 343.599°C at 760 mmHg
• Flash Point: 161.603°C
• Appearance: /
• Density: 1.279g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: (3-phenyl-1,2,4-oxadiazol-5-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-phenyl-1,2,4-oxadiazol-5-yl)methanol(5543-33-9)
• EPA Substance Registry System: (3-phenyl-1,2,4-oxadiazol-5-yl)methanol(5543-33-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5543-33-9(Hazardous Substances Data)

Usage

Description

(3-phenyl-1,2,4-oxadiazol-5-yl)methanol is a chemical compound with the molecular formula C9H7N3O2. It is a white solid with a molecular weight of 189.17 g/mol. (3-phenyl-1,2,4-oxadiazol-5-yl)methanol is a derivative of oxadiazole and is commonly used as a building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
(3-phenyl-1,2,4-oxadiazol-5-yl)methanol is used as a building block for the development of new drugs due to its unique chemical properties and potential for further research and development.
Used in Material Science:
(3-phenyl-1,2,4-oxadiazol-5-yl)methanol is used as a component in the design of novel materials, leveraging its versatile chemical structure and potential applications.
Used in Biological Studies:
(3-phenyl-1,2,4-oxadiazol-5-yl)methanol may be utilized as a fluorescent probe, enabling researchers to study biological processes and interactions with greater precision and detail.
Used in Coordination Chemistry:
(3-phenyl-1,2,4-oxadiazol-5-yl)methanol serves as a ligand in coordination chemistry, contributing to the development of new complexes and compounds with specific properties and applications.

InChI:InChI=1/C9H8N2O2/c12-6-8-10-9(11-13-8)7-4-2-1-3-5-7/h1-5,12H,6H2

Upstream product

• 5543-31-7 5-acetoxymethyl-3-phenyl-[1,2,4]oxadiazole 
• 1822-94-2 5-(chloromethyl)-3-phenyl-1,2,4-oxadiazole 
• 623-50-7 ethyl 2-hydroxyacetate 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 1544566-03-1 N-(2-((tert-butyldimethylsilyl)oxy)acetoxy)benzimidamide 
• 942-87-0 N'-acetoxybenzimidamide 
• 67226-76-0 (tert-butyldimethylsiloxy) acetic acid tert-butyldimethylsilyl ester 

Relevant articles and documents

Construction of 3,5-substituted 1,2,4-oxadiazole rings triggered by tetrabutylammonium hydroxide: A highly efficient and fluoride-free ring closure reaction of O-acylamidoximes

Tetrabutylammonium hydroxide (TBAH) is an efficient and mild alternative to tetrabutylammonium fluoride (TBAF) for base catalyzed cyclizations of 1,2,4-oxadiazoles from O-acylamidoximes. For most 3,5-substituted 1,2,4-oxadiazoles the reactions were dramatically accelerated by addition of 0.1 equiv of TBAH at room temperature. This method was also more generally applicable allowing for a wider range of substrates. Additionally, due to the absence of fluoride, TBAH will not result in corrosion of reactor vessels and therefore is better suited for large-scale synthesis.

Metabolities of 3-phenyl-5-methyl-1,2,4-oxadiazole (PMO) in rats, dogs, and mice.

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