5544-77-4

Basic information

• Product Name: (3-NITROPHENOXY) ACETIC ACID ETHYL ESTER
• Synonyms: (3-NITROPHENOXY) ACETIC ACID ETHYL ESTER
• CAS NO: 5544-77-4
• Molecular Formula: C₁₀H₁₁NO₅
• Molecular Weight: 225.2
• Mol File: 5544-77-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 342°C at 760 mmHg
• Flash Point: 153.7°C
• Appearance: /
• Density: 1.263g/cm³
• Vapor Pressure: 7.75E-05mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: (3-NITROPHENOXY) ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (3-NITROPHENOXY) ACETIC ACID ETHYL ESTER(5544-77-4)
• EPA Substance Registry System: (3-NITROPHENOXY) ACETIC ACID ETHYL ESTER(5544-77-4)

Safety Data

• Hazardous Substances Data: 5544-77-4(Hazardous Substances Data)

Usage

General Description

The chemical (3-NITROPHENOXY) ACETIC ACID ETHYL ESTER, also known as ethyl (3-nitrophenoxy)acetate, is an ethyl ester derivative of 3-nitrophenoxyacetic acid. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agricultural chemicals. (3-NITROPHENOXY) ACETIC ACID ETHYL ESTER is a colorless to pale yellow liquid with a slightly sweet odor, and it is soluble in organic solvents such as alcohol and ether. Its main applications include its use as a chemical intermediate and in the production of herbicides, insecticides, and fungicides. Additionally, it can also be used in the manufacturing of dyes, pigments, and other organic compounds.

InChI:InChI=1/C10H11NO5/c1-2-15-10(12)7-16-9-5-3-4-8(6-9)11(13)14/h3-6H,2,7H2,1H3

Upstream product

• 64-17-5 ethanol 
• 40257-02-1 3-nitrophenoxyacetyl chloride 
• 554-84-7 meta-nitrophenol 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 1878-88-2 2-(3-nitrophenoxy)acetic acid 

Downstream Products

• 58559-52-7 3-aminophenoxyacetic acid ethyl ester 
• 159213-86-2 2-[3-(phenylsulfonyl)aminophenoxy]-acetic acid ethyl ester 
• 159213-95-3 2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid ethyl ester 
• 159213-96-4 2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid 
• 159213-97-5 2-([3-(phenylsulfonyl)-N-methylamino-phenoxy]-4-pyridyl) acetamide 
• 205694-18-4 ethyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]amino}phenoxy)acetate 
• 205694-34-4 ethyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate 
• 205694-28-6 ethyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate 
• 916438-53-4 N-methyl-3-nitrophenoxyacetamide 
• 1878-88-2 2-(3-nitrophenoxy)acetic acid 
• 1263183-98-7 C₉H₁₀N₄O₄S 
• 1263183-85-2 C₁₃H₁₀N₄O₄S 
• 36304-45-7 (3-nitrophenoxy)acetic acid hydrazide 
• 299935-53-8 5-(3-nitro-phenoxymethyl)-[1,3,4]thiadiazol-2-ylamine 

Relevant articles and documents

The synthesis and evaluation of phenoxyacylhydroxamic acids as potential agents for Helicobacter pylori infections

Two series of ω-phenoxy contained acylhydroxamic acids as novel urease inhibitors were designed and synthesized. Biological activity evaluations revealed that ω-phenoxypropinoylhydroxamic acids were more active than phenoxyacetohydroxamic acids. Out of these compounds, 3-(3,4-dichlorophenoxy)propionylhydroxamic acid c24 showed significant potency against urease in both cell free extract (IC50 = 0.061 ± 0.003 μM) and intact cell (IC50 = 0.89 ± 0.05 μM), being over 450- and 120-fold more potent than the clinically prescribed urease inhibitor AHA, repectively. Non-linear fitting of experimental data (V-[S]) suggested a mixed-type inhibition mechanism and a dual site binding mode of these compounds.

Synthesis and Herbicidal Activity of Some Novel Pyrazole Derivatives

Some novel pyrazole derivatives were designed and synthesized through multi-step reactions from substituted phenol as starting material. Their structures were confirmed by 1H NMR, FTIR, MS and elemental analysis. All these compounds were evaluated their herbicidal activity. The preliminary bioassay results indicated that some of title compounds displayed moderate herbicidal activity at 200 μg/mL. Among them, compounds 4-chloro-N'-(2-(2,5-dimethyl-phenoxy) acetyl)-3-ethyl-1-methyl-1H-pyrazole-5-carbohydrazide, 4-chloro-N'-(2-(2,4-dichlorophenoxy)acetyl)- 3-ethyl-1-methyl-1H-pyrazole-5-carbohydrazide, 4-chloro-3-ethyl-1-methyl-N'-(2-(m-tolyloxy) acetyl)-1H-pyrazole-5-carbohydrazide and 4-chloro-3-ethyl-1-methyl-N'-(2-(3-nitrophenoxy)acetyl)- 1H-pyrazole-5-car-bohydrazide possessed 95%, 100%, 95% and 95% inhibition against Brassica campestris respectively. In the further bioassay, the compound 6l exhibited excellent herbicidal activity either monocotyledon or dicotyledon plant at 150 g/ha.

2,4-Pyrimidinediamine Compounds and Their Uses

The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.