555-48-6Relevant articles and documents
Ditertiary phosphines bearing a –N–C–C(O)–N(H)– linker and their corresponding dichloroplatinum(II) complexes
Elsegood, Mark R. J.,Lake, Andrew J.,Smith, Martin B.,Weaver, George W.
, p. 540 - 544 (2019)
The preparation of a small library of new –N–C–C(O)–N(H)– modified ditertiary phosphines is reported along with their square-planar dichloroplatinum(II) complexes. All compounds were characterized by 31P{1H} and 1H NMR spectroscopy, FT–IR spectroscopy and elemental analysis. The single crystal X-ray structures of four PtII complexes have been determined. Intra- (N–H···N) and intermolecular (N–H···N) hydrogen bonding is principally observed.
New isoleucine derived dipeptides as antiprotozoal agent: Synthesis, in silico and in vivo studies.
Ekoh, Ogechi C.,Okoro, Uchechukwu C.,Ali, Rafat,Ugwu, David I.,Okafor, Sunday N.,Ezugwu, James A.
, (2021/02/12)
The increasing emergence of malaria drug-resistant parasites and the deficiency in effective chemotherapy for trypanosomiasis represents a huge challenge in infectious disease treatment in tropical regions. As regards to developing effective antiprotozoal agents, ten new ile-gly dipeptide sulphonamide derivatives were synthesized by condensing compound (10) with (8a-j)using peptide coupling reagents. Compounds11b, 11i and 11j were most potent in clearing Trypanosome brucei in mice with 11b showing comparable activity with diminazene aceturate. In the antimalarial study, 11b was the most active compound, even better than the standard. Molecular docking result suggests good interaction between the reported compounds and the target protein. The results of haematological analysis, liver and kidney function tests showed that the compounds had no adverse effect on the blood and organs. Compound 11b stands out amongst the derivatives haven shown better activity in both the antimalarial and antitrypanosomal assay.
Vorinostat skeleton-based anthranilamide compound as well as preparation and application thereof
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Paragraph 0025; 0027, (2021/08/06)
The invention provides a vorinostat skeleton-based anthranilamide compound as well as preparation and application of the anthranilamide compound. The structural formula of the o-aminobenzamide compound based on a vorinostat skeleton is shown in the specification, wherein n is equal to 1-6, and R is methylamino, dimethylamino, hydroxyl, NH2 or the like. The anthranilamide compound based on the vorinostat skeleton has the effect of inhibiting gastric cancer cell proliferation through MTT method determination, and can be used for preparing anti-gastric cancer drugs.
