55525-14-9

Basic information

• Product Name: 1,1-bis(4-chlorophenyl)propan-2-one
• CAS NO: 55525-14-9
• Molecular Formula: C₁₅H₁₂Cl₂O
• Molecular Weight: 279.1612
• Mol File: 55525-14-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 373.6°C at 760 mmHg
• Flash Point: 158°C
• Density: 1.248g/cm³
• Vapor Pressure: 8.85E-06mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 1,1-bis(4-chlorophenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-bis(4-chlorophenyl)propan-2-one(55525-14-9)
• EPA Substance Registry System: 1,1-bis(4-chlorophenyl)propan-2-one(55525-14-9)

Safety Data

• Hazardous Substances Data: 55525-14-9(Hazardous Substances Data)

Upstream product

• 996-82-7 sodium diethylmalonate 
• 68668-89-3 2,2-bis(4-chlorophenyl)acetyl chloride 
• 122135-77-7 1,1-bis(4-chlorophenyl)propane-1,2-diol 
• 97-64-3 ethyl 2-hydroxypropionate 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 50-29-3 p,p'-DDT 
• 83-05-6 bis(4'-chlorophenyl)acetic acid 
• 106-39-8 bromochlorobenzene 
• 67-64-1 acetone 
• 5586-88-9 1-(4-chlorophenyl)propan-2-one 

Downstream Products

• 62897-66-9 2,2-dichloro-1,1-bis-(4-chloro-phenyl)-propane 
• 6941-84-0 1,1-bis-(4-chloro-phenyl)-acetone oxime 
• 92907-46-5 1,1-bis-(4-chloro-phenyl)-acetone semicarbazone 
• 1042964-70-4 3,3-bis(4-chlorophenyl)-2-methylprop-1-ene-1,1-dicarbonitrile 
• 6941-84-0 C₁₅H₁₃Cl₂NO 
• 86147-03-7 α-ethenyl-α-(4-chlorophenyl)-4-chlorobenzenemethanol 

Relevant articles and documents

Benzyl C–O and C–N Bond Construction via C–C Bond Dissociation of Oxime Ester under Visible Light Irradiation

A photoredox benzyl activation was developed via formidable C(sp3)–C(sp3) bond dissociation of 1-aryl acetone oxime esters, which were easily prepared from benzyl ketones. Further coupling with O- and N- nucleophiles successfully forged important benzyl ether and amines derivatives in one pot. In this process, different substitutions on oxime esters were found compatible and various primary and secondary alcohols and amines, as well as amides showed good performance as nucleophiles. Mechanistic studies by control experiments, electrochemical measurements and in-situ NMR spectra proposed a N–O bond interruption/C–C bond fragmentation/oxidation sequence to provide the key cation intermediate for the next electrophilic SN process. The features of mild condition, short reaction time and broad substrate scope made this new strategy much promising in the transformation of benzyl compounds, which might be valuable in last-stage functionalizations.

Palladium-catalyzed amination of aromatic C-H bonds with oxime esters

"Chemical equation presented" We report a conceptually new approach to the direct amination of aromatic C-H bonds. In this process, an oxime ester function reacts with an aromatic C-H bond under redox-neutral conditions to form, in the case studied, an indole product. These reactions occur with relatively low catalyst loading (1 mol %) by a mechanism that appears to involve an unusual initial oxidative addition of an N-O bond to a Pd(0) species. The Pd(II) complex from oxidative addition of the N-X bond has been isolated for the first time, and evidence for the intermediacy of such oxidative addition products in the catalytic reaction has been gained.