5554-37-0Relevant articles and documents
A kind of α-hydroxy amides the synthetic method of the compound of
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Paragraph 0128-0136, (2016/10/07)
The invention provides a method for synthesizing an alpha-hydroxy amide compound. The method specifically comprises the following steps: (1) mixing amide, an alkali and dimethyl sulfoxide, sealing in an air atmosphere, and reacting; (2) cooling to room te
Nucleophilic Addition of Lanthanoid Metal Umpoled Diaryl Ketones to Electrophiles
Hou, Zhaomin,Takamine, Kan,Aoki, Osamu,Shiraishi, Hiroyuki,Fujiwara, Yuzo,Taniguchi, Hiroshi
, p. 6077 - 6084 (2007/10/02)
Ytterbium metal promoted cross-coupling reactions of diaryl ketones with a variety of electrophiles are described.Diaryl ketones treated with 1-2 equiv of Yb metal react smoothly with other ketones, nitriles, epoxides, CO2, etc., to give the corresponding unsymmetrical pinacols, α-hydroxy ketones, 1,3-diols, α-hydroxy carboxylic acids, etc., in good yields respectively.These reactions occur via nucleophilic addition of the intermediates 4a-c to electrophiles.Reaction of benzophenone (1a) with Yb metal is discussed in detail and some information on the composition of the intermediates of the reaction of diaryl ketones with Yb metal are also given.